Chopin P, Debeir T, Raisman-Vozari R, Colpaert F C, Marien M R
Centre de Recherche Pierre Fabre, 81106 Castres Cedex, France.
Exp Neurol. 2004 Jan;185(1):198-200. doi: 10.1016/j.expneurol.2003.09.010.
The alpha2-adrenoceptor antagonist, dexefaroxan, has been shown in the rat to have neuroprotective and plastic effects against degenerative structural changes in elements of the basalocortical cholinergic system that result from cortical devascularization [Neuroscience 115 (2002) 41]. The present study, using the same experimental protocol, examined the functional consequences of cortical devascularization and dexefaroxan treatment in the Morris water maze memory test. Rats were first trained to find the hidden platform in the test, and then subjected to the devascularization procedure. Thirty-one days later, lesioned rats exhibited a significant deficit in recalling the platform location, compared with sham control animals. A 28-day subcutaneous infusion with dexefaroxan (0.63, 2.5, and 10 mg rat(-1) day(-1)), starting from the moment of the devascularization, protected against this spatial memory deficit.
α2 -肾上腺素能受体拮抗剂右苯氧胺，在大鼠实验中已显示出对基底皮质胆碱能系统因皮质缺血导致的退行性结构变化具有神经保护和可塑性作用[《神经科学》115 (2002) 41]。本研究采用相同实验方案，在莫里斯水迷宫记忆测试中检验了皮质缺血及右苯氧胺治疗的功能后果。首先训练大鼠在测试中找到隐藏平台，然后进行缺血手术。31天后，与假手术对照组动物相比，损伤大鼠在回忆平台位置方面表现出显著缺陷。从缺血时刻开始，连续28天皮下输注右苯氧胺（0.63、2.5和10毫克/大鼠/天）可预防这种空间记忆缺陷。
