儿茶酚胺神经递质单胺氧化酶代谢产物的神经毒性：在神经退行性疾病中的作用。
Neurotoxicity of MAO metabolites of catecholamine neurotransmitters: role in neurodegenerative diseases.
作者信息
Burke William J, Li Shu Wen, Chung Hyung D, Ruggiero David A, Kristal Bruce S, Johnson Eugene M, Lampe Patricia, Kumar Vijaya B, Franko Mark, Williams Evelyn A, Zahm Daniel S
机构信息
Department of Neurology, Veterans Affairs Medical Center, Saint Louis University Health Sciences Center, St. Louis, MO 63110, USA.
出版信息
Neurotoxicology. 2004 Jan;25(1-2):101-15. doi: 10.1016/S0161-813X(03)00090-1.
The monoamine oxidase (MAO) metabolites of norepinephrine (NE) or epinephrine (EPI) and of dopamine (DA) are 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL) and 3,4-dihydroxyphenylacetaldehyde (DOPAL), respectively. The toxicity of these catecholamine (CA) MAO metabolites was predicted over 50 years ago. However, until our recent chemical synthesis of these CA aldehyde metabolites, the hypothesis about their toxicity could not be tested. The present paper reviews recent knowledge gained about these compounds. Topics to be reviewed include: chemical synthesis and properties of DOPEGAL and DOPAL; in vitro and in vivo toxicity of CA aldehydes; subcellular mechanisms of toxicity; free radical formation by DOPEGAL versus DOPAL; mechanisms of accumulation of CA aldehydes in Alzheimer's disease (AD) and Parkinson's disease (PD) and potential therapeutic targets in Alzheimer's disease and Parkinson's disease.
去甲肾上腺素（NE）或肾上腺素（EPI）以及多巴胺（DA）的单胺氧化酶（MAO）代谢产物分别是3,4 - 二羟基苯乙醇醛（DOPEGAL）和3,4 - 二羟基苯乙醛（DOPAL）。这些儿茶酚胺（CA）MAO代谢产物的毒性在50多年前就已被预测。然而，直到我们最近对这些CA醛类代谢产物进行化学合成，关于它们毒性的假说才得以验证。本文综述了有关这些化合物的最新知识。将被综述的主题包括：DOPEGAL和DOPAL的化学合成及性质；CA醛类的体外和体内毒性；毒性的亚细胞机制；DOPEGAL与DOPAL产生自由基的情况；CA醛类在阿尔茨海默病（AD）和帕金森病（PD）中的蓄积机制以及阿尔茨海默病和帕金森病中的潜在治疗靶点。
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