Department of Chemistry, University of Nairobi, Nairobi, Kenya.
Planta Med. 2012 Jan;78(1):31-5. doi: 10.1055/s-0031-1280179. Epub 2011 Oct 6.
The dichloromethane/methanol (1:1) extracts of the roots of Pentas longiflora and Pentas lanceolata showed low micromolar (IC(50) = 0.9-3 µg/mL) IN VITRO antiplasmodial activity against chloroquine-resistant (W2) and chloroquine-sensitive (D6) strains of PLASMODIUM FALCIPARUM. Chromatographic separation of the extract of PENTAS LONGIFLORA led to the isolation of the pyranonaphthoquinones pentalongin (1) and psychorubrin (2) with IC(50) values below 1 µg/mL and the naphthalene derivative mollugin (3), which showed marginal activity. Similar treatment of Pentas lanceolata led to the isolation of eight anthraquinones ( 4-11, IC(50) = 5-31 µg/mL) of which one is new (5,6-dihydroxydamnacanthol, 11), while three--nordamnacanthal (7), lucidin-ω-methyl ether (9), and damnacanthol (10)--are reported here for the first time from the genus Pentas. The compounds were identified by NMR and mass spectroscopic techniques.
五列木和长隔木的根的二氯甲烷/甲醇（1:1）提取物对氯喹耐药（W2）和氯喹敏感（D6）株 PLASMODIUM FALCIPARUM 表现出低微摩尔（IC（50）= 0.9-3μg/mL）的体外抗疟活性。从五列木提取物的色谱分离得到具有低于 1μg/mL 的 IC（50）值的吡喃并萘醌化合物 pentalongin（1）和 psychorubrin（2），以及具有边缘活性的萘衍生物 mollugin（3）。对长隔木进行类似的处理导致分离出八种蒽醌（4-11，IC（50）= 5-31μg/mL），其中一种是新的（5,6-二羟基 damnacanthol，11），而三种- nordamnacanthal（7）， lucidin-ω-甲醚（9）和 damnacanthol（10）-是首次从五列木属中报道的。通过 NMR 和质谱技术鉴定了这些化合物。
