Okubo T, Usami S, Kamiya Y, Takeuchi Y, Kotani H, Shinagawa N, Yura J
Department of Surgery, Kariya General Hospital, Japan.
Nihon Geka Gakkai Zasshi. 1992 Sep;93(9):918-21.
Candida spp. is frequently detected from perioperative patients, especially from those requiring central venous catheter (CVC) management. CAND-TEC could detect the blood fungus infection easily and quickly. We analyzed 438 specimens from 57 patients requiring perioperative CVC management for more than three weeks, and investigated usefulness of CAND-TEC comparing with other serological methods. The dilution rate of CAND-TEC showed a positive correlation with amount of beta-D-glucan which was measured by Toxicolor test and Endotoxin-specific assay. It also showed a positive correlation with amount of D-arabinitol. When blood samples diluted more than four times were positive with CAND-TEC, the patients were considered to be infected, and accumulative infection rate was up to 84.2% three weeks after introduction of CVC management. CAND-TEC would be useful in detecting Candida infection compared with conventional methods, and the fungus infection was much more frequent incidence than ever expected. It is important to detect fungus infection early and respond immediately to avoid nosocomial infection.
念珠菌属经常在围手术期患者中被检测到，尤其是那些需要中心静脉导管（CVC）管理的患者。CAND-TEC能够轻松快速地检测出血液真菌感染。我们分析了57例需要进行超过三周围手术期CVC管理的患者的438份标本，并与其他血清学方法比较，研究了CAND-TEC的实用性。CAND-TEC的稀释率与通过Toxicolor试验和内毒素特异性测定法测量的β-D-葡聚糖量呈正相关。它还与D-阿拉伯糖醇量呈正相关。当CAND-TEC检测到稀释超过四倍的血样呈阳性时，这些患者被认为受到感染，在引入CVC管理三周后累积感染率高达84.2%。与传统方法相比，CAND-TEC在检测念珠菌感染方面将很有用，并且真菌感染的发生率比以往预期的要高得多。早期检测真菌感染并立即做出反应以避免医院感染很重要。
