Balédent Olivier, Gondry-Jouet Catherine, Meyer Marc-Etienne, De Marco Giovanni, Le Gars Daniel, Henry-Feugeas Marie-Cécile, Idy-Peretti Ilana
Department of Imaging and Biophysics, UMR 6600 CNRS, Teaching Hospitals, Jules Verne University of Picardie, Amiens, France.
Invest Radiol. 2004 Jan;39(1):45-55. doi: 10.1097/01.rli.0000100892.87214.49.
Using magnetic resonance imaging (MRI), we investigated cerebral blood and cerebrospinal fluid (CSF) flows in patients with communicating hydrocephalus (CH) and in healthy volunteers to determine the contribution of CSF flow to brain pressure regulation in CH patients.
Cine phase-contrast MRI data from 16 healthy volunteers and 12 patients with CH characterized by hyperdynamic aqueductal CSF flow were analyzed using in-house image-processing software that automatically measured flow curves. Amplitude and temporal CSF and blood flow parameters were compared in the 2 groups.
Jugular peak flow occurred significantly earlier (P < 0.01) in the CH patients than in the healthy volunteers. Cervical CSF oscillations were not significantly different between the 2 groups.
Venous vessel compression and/or changes in intracranial subarachnoid CSF flow produce an increase in ventricular CSF flush that compensates for vascular brain expansion in patients with CH.
我们使用磁共振成像（MRI）研究了交通性脑积水（CH）患者和健康志愿者的脑血流及脑脊液（CSF）流动情况，以确定脑脊液流动对CH患者脑压调节的作用。
使用内部图像处理软件分析了16名健康志愿者和12名以导水管CSF流动活跃为特征的CH患者的电影相位对比MRI数据，该软件可自动测量血流曲线。比较了两组的CSF和血流参数的幅度及时间特征。
CH患者的颈静脉峰值血流出现时间明显早于健康志愿者（P < 0.01）。两组之间的颈段CSF振荡无显著差异。
静脉血管受压和/或颅内蛛网膜下腔CSF流动变化导致脑室CSF冲洗增加，从而补偿CH患者的脑实质血管扩张。
