Henning Jill D, Karamchandani Jaideep M, Bonachea Luis A, Bunker Clareann H, Patrick Alan L, Jenkins Frank J
Department of Biology, University of Pittsburgh Johnstown, Johnstown, PA.
Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, PA.
Prostate. 2017 May;77(6):617-624. doi: 10.1002/pros.23308. Epub 2017 Jan 24.
Serum-prostate specific antigen (PSA) levels have been used for many years as a biomarker for prostate cancer. This usage is under scrutiny due to the fact that elevated PSA levels can be caused by other conditions such as benign prostatic hyperplasia and infections of or injury to the prostate. As a result, the identification of specific pathogens capable of increasing serum levels of PSA is important. A potential candidate responsible for elevated PSA is human herpesvirus 8 (HHV-8). We have reported previously that HHV-8 is capable of infecting and establishing a latent infection in the prostate. In this current study we test the hypothesis that HHV-8 infection is associated with elevated PSA levels. Circulating cytokine levels between men with elevated PSA and controls are also compared.
HHV-8 serostatus was determined among men with elevated serum PSA (≥4 ng/ml; n = 168, no prostate cancer on biopsy) and age-matched controls (PSA <4 ng/ml; n = 234), Circulating cytokine levels were determined among a subset of each group (116 with elevated PSA and 85 controls).
Men with an elevated serum PSA were significantly more likely to be HHV-8 seropositive (42.9%) than the age-matched cancer-free men (22.2%; OR 2.51; 95%CI 1.48-4.29, P = 00001). Comparison of circulating cytokine levels between men with elevated serum PSA and controls indicated that elevated serum PSA is associated with a pro-inflammatory response with a mixed Th1/Th2 response while HHV-8 infection was associated with significantly higher levels of IL12p70, IL-10, and IL-13 indicating a Th2 immune response.
We found a significant association between HHV-8 infection and increased levels of serum PSA. In an age of patient-centered medicine, men with an elevated serum PSA should be considered for HHV-8 serology testing to determine if HHV-8 is responsible for the elevated PSA. Prostate 77: 617-624, 2017. © 2017 Wiley Periodicals, Inc.
血清前列腺特异性抗原（PSA）水平多年来一直被用作前列腺癌的生物标志物。由于PSA水平升高可能由其他疾病引起，如良性前列腺增生以及前列腺感染或损伤，这种用法正受到审视。因此，识别能够升高血清PSA水平的特定病原体很重要。一种导致PSA升高的潜在病原体是人类疱疹病毒8型（HHV-8）。我们之前曾报道HHV-8能够感染前列腺并在其中建立潜伏感染。在本研究中，我们检验HHV-8感染与PSA水平升高相关的假设。同时也比较了PSA升高的男性与对照组之间的循环细胞因子水平。
在血清PSA升高（≥4 ng/ml；n = 168，活检未发现前列腺癌）的男性和年龄匹配的对照组（PSA < 4 ng/ml；n = 234）中测定HHV-8血清学状态。在每组的一个亚组中（116例PSA升高者和85例对照组）测定循环细胞因子水平。
血清PSA升高的男性HHV-8血清阳性的可能性（42.9%）显著高于年龄匹配的无癌男性（22.2%；OR 2.51；95%CI 1.48 - 4.29，P = 0.0001）。血清PSA升高的男性与对照组之间循环细胞因子水平的比较表明，血清PSA升高与混合Th1/Th2反应的促炎反应相关，而HHV-8感染与显著更高水平的IL12p70、IL-10和IL-13相关，表明存在Th2免疫反应。
我们发现HHV-8感染与血清PSA水平升高之间存在显著关联。在以患者为中心的医学时代，对于血清PSA升高的男性，应考虑进行HHV-8血清学检测，以确定HHV-8是否是导致PSA升高的原因。《前列腺》77: 617 - 624, 2017。© 2017威利期刊公司。
