Yeh E Ann, Collins Arlene, Cohen Michael E, Duffner Patricia K, Faden Howard
Department of Neurology, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York, USA.
Pediatrics. 2004 Jan;113(1 Pt 1):e73-6. doi: 10.1542/peds.113.1.e73.
We present a case in which human coronavirus was detected in the cerebrospinal fluid of a child presumed to have acute disseminated encephalomyelitis. In murine models, coronavirus has been found to cause a chronic demyelinating condition that resembles multiple sclerosis. Additionally, there is in vitro evidence of human coronavirus's ability to infect neural cells. This case report provides additional support for the hypothesis that coronavirus may be an important etiologic factor in the pathogenesis of demyelinating disease in humans.
我们报告了一例在一名疑似患有急性播散性脑脊髓炎的儿童脑脊液中检测出人类冠状病毒的病例。在小鼠模型中，已发现冠状病毒可引发一种类似于多发性硬化症的慢性脱髓鞘疾病。此外，有体外证据表明人类冠状病毒具有感染神经细胞的能力。本病例报告为冠状病毒可能是人类脱髓鞘疾病发病机制中的重要病因这一假说提供了更多支持。
