急性单症状性视神经炎患者脑脊液中的冠状病毒
Coronaviruses in spinal fluid of patients with acute monosymptomatic optic neuritis.
作者信息
Dessau R B, Lisby G, Frederiksen J L
机构信息
Department of Clinical Microbiology, Herlev University Hospital, Denmark.
出版信息
Acta Neurol Scand. 1999 Aug;100(2):88-91. doi: 10.1111/j.1600-0404.1999.tb01043.x.
UNLABELLED
Acute monosymptomatic optic neuritis (AMON) may be an initial symptom of multiple sclerosis (MS). Coronaviruses have been implicated in the etiology of MS. The objective of the present study was to look for coronaviral RNA in AMON, which could be present in the initial stages of the development of MS.
MATERIAL AND METHODS
Spinal fluids from 37 patients with AMON and 15 surgical control patients with protrusion of the intervertebral disk were assayed with a nested multiplex polymerase chain reaction with primers specific for human coronaviruses strain (HCV) 229E and OC43.
RESULTS
Four patients and 1 control were positive for HCV-229E. No evidence of HCV-OC43 was found. The frequency of positive samples was low and there was no statistical difference between AMON and controls.
CONCLUSION
This study does not provide evidence for an etiological role of human coronaviruses in acute monosymptomatic optic neuritis.
未标记
急性单症状性视神经炎（AMON）可能是多发性硬化症（MS）的初始症状。冠状病毒被认为与MS的病因有关。本研究的目的是在AMON中寻找冠状病毒RNA，其可能存在于MS发展的初始阶段。
材料与方法
采用巢式多重聚合酶链反应，用针对人类冠状病毒株（HCV）229E和OC43的引物，对37例AMON患者和15例椎间盘突出症手术对照患者的脑脊液进行检测。
结果
4例患者和1例对照的HCV-229E呈阳性。未发现HCV-OC43的证据。阳性样本的频率较低，AMON组与对照组之间无统计学差异。
结论
本研究未提供人类冠状病毒在急性单症状性视神经炎中具有病因学作用的证据。
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