Nayar Amith K, Sundharam B Sivapatha
Department of Oral Pathology, Meenakshi Ammal Dental College, Chennai, India.
Indian J Dent Res. 2003 Apr-Jun;14(2):87-93.
Interest in the field of oral exfoliative cytology has reemerged following advancements in the field of quantitative oral exfoliative cytology as a powerful diagnostic tool. However, even though numerous such studies have been conducted in malignant and precancerous conditions, there have been relatively few reports of similar studies on the normal mucosa, which could be used as a baseline for comparison of pathological smears. This study was undertaken to establish the average nuclear diameter (ND), cytoplasmic diameter (CD), and the nuclear cytoplasmic (NC) ratio in normal subject and to evaluate the differences in these parameters, if any, between different age groups and between males and females. The mean ND was found to range from 7.8 u to 8.28 mu, the mean CD was found to range from 46.19 mu, and the NC ratio was found to range from 0.1609 to 1822. The results of this study also showed significant variation in the CD with increasing age. All parameters showed variations with age changes in females, probably as a result of hormonal influences.
随着定量口腔脱落细胞学领域的进展，其作为一种强大的诊断工具，口腔脱落细胞学领域再次受到关注。然而，尽管已经针对恶性和癌前病变进行了大量此类研究，但关于正常黏膜的类似研究报告相对较少，而正常黏膜可作为病理涂片比较的基线。本研究旨在确定正常受试者的平均核直径（ND）、细胞质直径（CD）和核质（NC）比，并评估这些参数在不同年龄组以及男性和女性之间是否存在差异。发现平均ND范围为7.8微米至8.28微米，平均CD范围为46.19微米，NC比范围为0.1609至0.1822。本研究结果还显示，随着年龄增长，CD存在显著变化。所有参数在女性中均随年龄变化而变化，这可能是激素影响的结果。
