新型5(1H) - 氧代 - 2,3 - 二氢咪唑并[1,2 - a]嘧啶 - 6 - 羧酸酯的合成及其某些中枢药理学性质
Synthesis and some central pharmacological properties of new 5(1H)oxo-2,3-dihydroimidazo[1,2-a]pyrimidine-6-carboxylic esters.
作者信息
Matosiuk D, Tkaczyński T, Jagiełło-Wójtowicz E, Wielosz M, Szurska G, Chodkowska A, Janusz W, Kleinrok Z
机构信息
Department of Chemical Technology of Drugs, Medical Academy, Lublin, Poland.
出版信息
Pol J Pharmacol Pharm. 1992 May-Jun;44(3):307-18.
PMID:1470568
Abstract
Six new 5(1H)oxo-2,3-dihydroimidazo[1,2-a]pyrimidine-6-carboxylic ethyl esters bearing an aromatic substituent in position 1 or 2 were obtained. Pharmacological studies on the central action of these derivatives were carried out on mice and rats. The highest activity showed compounds 1 and 2 which produced analgesic effects in mice.
摘要
得到了6个在1位或2位带有芳族取代基的新型5(1H)氧代-2,3-二氢咪唑并[1,2-a]嘧啶-6-羧酸乙酯。对这些衍生物的中枢作用进行了小鼠和大鼠的药理学研究。化合物1和2表现出最高活性，它们对小鼠产生了镇痛作用。
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