某些2,4-二氧代-1,2,3,4,5,6,7,8-八氢嘧啶并[4,5-d]嘧啶的合成、化学及药理性质
Synthesis, chemical and pharmacological properties of some 2,4-dioxo-1,2,3,4,5,6,7,8-octahydropyrimido [4,5-d]pyrimidines.
作者信息
Sladowska H, Sieklucka-Dziuba M, Rajtar G, Wydro R, Kleinrok Z
机构信息
Department of Chemistry of Drugs, Wrocław University of Medicine, Poland.
出版信息
Acta Pol Pharm. 1996 Jan-Feb;53(1):39-46.
PMID:8960282
Abstract
Synthesis of 6-substituted 2,4-dioxo-1,2,3,4,5,6,7,8-octahydropyrimido[4,5-d]pyrimidines [III-VI] obtained by cyclocondensation of 1-phenyl-6-aminouracil with formaline and the primary amines is described. Compounds III, V, VI in the Mannich reaction with secondary cyclic amines yield the corresponding 3-substituted N-aminomethyl derivatives VII-X. Some of them were active pharmacologically.
摘要
描述了通过1-苯基-6-氨基尿嘧啶与福尔马林和伯胺的环缩合反应合成6-取代的2,4-二氧代-1,2,3,4,5,6,7,8-八氢嘧啶并[4,5-d]嘧啶[III-VI]的方法。化合物III、V、VI与仲环胺在曼尼希反应中生成相应的3-取代的N-氨甲基衍生物VII-X。其中一些具有药理活性。
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