Iwu M M, Jackson J E, Tally J D, Klayman D L
Department of Medicinal Chemistry, Walter Reed Army Institute of Research, Washington, D.C. 20307.
Planta Med. 1992 Oct;58(5):436-41. doi: 10.1055/s-2006-961508.
Extracts of eleven plants used in Nigerian traditional medicine have been evaluated for possible antileishmanial activity using a radiorespirometric microtest technique based on in vitro inhibition of catabolism of 14CO2 from a battery of 14C-substrates by promastigotes. Of 13 methanol extracts tested, 5 from Gongronema latifolia, Dorstenia multiradiata, Picralima nitida, Cola attiensis, and Desmodium gangeticum, were active at concentrations of 50 micrograms/ml or less against a visceral Leishmania isolate.
利用一种基于前鞭毛体对一系列¹⁴C底物的¹⁴CO₂分解代谢的体外抑制作用的放射性呼吸微量测试技术，对用于尼日利亚传统医学的11种植物提取物进行了潜在抗利什曼原虫活性评估。在所测试的13种甲醇提取物中，来自宽叶贡诺麻、多枝肉托果、亮叶 picralima、阿蒂可乐和恒河山蚂蝗的5种提取物，在浓度为50微克/毫升或更低时，对一种内脏利什曼原虫分离株具有活性。
