Bouziotas C, Koutedakis Y, Nevill A, Ageli E, Tsigilis N, Nikolaou A, Nakou A
School of Sport, Performing Arts and Leisure, University of Wolverhampton, UK.
Arch Dis Child. 2004 Jan;89(1):41-4.
A dramatic increase in adult mortality rates from coronary heart disease (CHD) in Greece, accompanied by increased prevalence of CHD risk factors in children, has been documented. However, there is controversy about the independent effects of certain lifestyle parameters on primary CHD risk factors.
To examine the association between CHD risk factors (HDL-C, LDL-C, HDL-C/TC, triglycerides, systolic and diastolic blood pressure) and lifestyle parameters (fitness, fatness, fat intake, and physical activity) in 210 12-year old Greek pupils.
Correcting for the fixed factors of gender and maturation, analyses of covariance (ANCOVA) with backward elimination of the lifestyle covariates revealed significant associations between three CHD risk factors (HDL-C, HDL-C/TC, systolic blood pressure) and physical activity levels. In contrast, the covariates aerobic fitness, fatness and fat intake failed to reach significance with any of the CHD risk factors.
In Greek schoolchildren, primary CHD risk factors are mainly associated with physical activity levels, independently of fitness, fatness, and/or fat intake. Prevention strategies should concentrate on enhancing physical activity early in life, if the increased prevalence of Greek adult CHD mortality is to be diminished.
希腊成人冠心病（CHD）死亡率急剧上升，同时儿童CHD危险因素患病率也有所增加，这已被记录在案。然而，某些生活方式参数对原发性CHD危险因素的独立影响存在争议。
在210名12岁希腊学生中，研究CHD危险因素（高密度脂蛋白胆固醇[HDL-C]、低密度脂蛋白胆固醇[LDL-C]、HDL-C/总胆固醇[TC]、甘油三酯、收缩压和舒张压）与生活方式参数（健康状况、肥胖程度、脂肪摄入量和身体活动）之间的关联。
校正性别和成熟度等固定因素后，采用协方差分析（ANCOVA）并逐步剔除生活方式协变量，结果显示三个CHD危险因素（HDL-C、HDL-C/TC、收缩压）与身体活动水平之间存在显著关联。相比之下，健康状况、肥胖程度和脂肪摄入量等协变量与任何CHD危险因素之间均未达到显著水平。
在希腊学童中，原发性CHD危险因素主要与身体活动水平相关，与健康状况、肥胖程度和/或脂肪摄入量无关。如果要降低希腊成人CHD死亡率的上升趋势，预防策略应集中在生命早期增强身体活动。
