来自尖叶紫玉盘的细胞毒性C-苄基二氢查耳酮。

Cytotoxic C-benzylated dihydrochalcones from Uvaria acuminata.

作者信息

Ichimaru Momoyo, Nakatani Noriyoshi, Takahashi Tomoko, Nishiyama Yumi, Moriyasu Masataka, Kato Atsushi, Mathenge Simon G, Juma Francis D, Nganga Joseph N

机构信息

Department of Natural Medicinal Chemistry, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan.

出版信息

Chem Pharm Bull (Tokyo). 2004 Jan;52(1):138-41. doi: 10.1248/cpb.52.138.

DOI:10.1248/cpb.52.138

PMID:14709883

Abstract

Two new C-benzylated dihydrochalcones, isochamuvaritin (1) and acumitin (2), have been isolated from the African medicinal plant Uvaria acuminata, together with the previously reported benzylbenzoate (3), uvaretin (4), isouvaretin (5), diuvaretin (6), and uvangoletin (7). The structural elucidation of compounds 1 and 2 in spectroscopic studies is described. C-Benzylated dihydrochalcones, especially 1, 2, 4, and 6, showed considerable cytotoxicity toward human promyelocytic leukemia HL-60 cells.

摘要

从非洲药用植物尖叶紫玉盘（Uvaria acuminata）中分离出了两种新的C-苄基二氢查耳酮，异查木瓦瑞亭（1）和尖叶紫玉盘素（2），同时还分离出了先前报道的苯甲酸苄酯（3）、紫玉盘素（4）、异紫玉盘素（5）、双氧紫玉盘素（6）和紫玉盘葛亭（7）。描述了化合物1和2在光谱研究中的结构解析。C-苄基二氢查耳酮，尤其是1、2、4和6，对人早幼粒细胞白血病HL-60细胞显示出相当大的细胞毒性。