Chemistry Department, College of Natural and Applied Sciences , University of Dar es Salaam , P.O. Box 35061, Dar es Salaam , Tanzania.
Department of Chemistry - BMC , Uppsala University , SE-751 23 Uppsala , Sweden.
J Nat Prod. 2020 Feb 28;83(2):210-215. doi: 10.1021/acs.jnatprod.9b00363. Epub 2020 Jan 27.
Three new oxygenated cyclohexene derivatives, trichocarpeols A (), B (), and C (), along with nine known secondary metabolites, were isolated from the methanolic root extract of . They were identified by NMR spectroscopic and mass spectrometric analyses, and the structure of trichocarpeol A () was confirmed by single-crystal X-ray diffraction. Out of the 12 isolated natural products, uvaretin () showed activity against the Gram-positive bacterium with a MIC value of 18 μM. None of the isolated metabolites was active against the Gram-negative at a ∼5 mM (2000 μg/mL) concentration. Whereas showed cytotoxicity at EC 10.2 μM against the MCF-7 human breast cancer cell line, the other compounds were inactive or not tested.
从 Trichocarpus wallichii 的甲醇根提取物中分离得到了三种新的含氧环己烯衍生物，即 trichocarpeols A()、B()和 C()，以及 9 种已知的次级代谢产物。通过 NMR 光谱和质谱分析进行了鉴定，trichocarpeol A()的结构通过单晶 X 射线衍射得到了确认。在所分离的 12 种天然产物中，uvaretin()对革兰氏阳性菌表现出活性，其 MIC 值为 18 μM。在所测试的浓度下（约 5 mM（2000 μg/mL）），没有一种分离的代谢产物对革兰氏阴性菌有活性。而化合物则对 MCF-7 人乳腺癌细胞系显示出 EC 10.2 μM 的细胞毒性，其他化合物则没有活性或未进行测试。
