Oxygenated Cyclohexene Derivatives and Other Constituents from the Roots of .

Three new oxygenated cyclohexene derivatives, trichocarpeols A (), B (), and C (), along with nine known secondary metabolites, were isolated from the methanolic root extract of . They were identified by NMR spectroscopic and mass spectrometric analyses, and the structure of trichocarpeol A () was confirmed by single-crystal X-ray diffraction. Out of the 12 isolated natural products, uvaretin () showed activity against the Gram-positive bacterium with a MIC value of 18 μM. None of the isolated metabolites was active against the Gram-negative at a ∼5 mM (2000 μg/mL) concentration. Whereas showed cytotoxicity at EC 10.2 μM against the MCF-7 human breast cancer cell line, the other compounds were inactive or not tested.