Wong Michael Y, Harmanli Ozgur H, Agar Mehmet, Dandolu Vani, Grody M H Terry
Department of Obstetrics, Gynecology, and Reproductive Sciences, Temple University School of Medicine, 3401 N. Broad Street, Philadelphia, PA 19140, USA.
Am J Obstet Gynecol. 2003 Dec;189(6):1597-9; discussion 1599-1600. doi: 10.1016/j.ajog.2003.09.043.
Reduction in the collagen content of the pelvic floor tissue of the patients with pelvic organ prolapse and/or stress urinary incontinence has been documented previously. However, this is less clear for nonsupport tissue. We aimed to compare the collagen content of the uterine cervix, a nonsupport tissue, of women who had pelvic organ prolapse with and without stress urinary incontinence against those without these problems.
Cervical collagen content was compared between 14 women who had pelvic organ prolapse with and without stress urinary incontinence and 17 controls without these conditions. Specimens were obtained after surgery for benign gynecologic conditions.
Groups were similar with respect to age, parity, body mass index, and tobacco use. Women who had pelvic organ prolapse with and without stress urinary incontinence possessed significantly less collagen compared with the controls (8.10%+/-3.43% vs 12.35%+/-4.72%, P=.0104). Furthermore age, parity, body mass index, or tobacco use had no significant relationship to collagen content.
Cervical collagen content is significantly decreased in women who have pelvic organ prolapse with and without stress urinary incontinence regardless of age, parity, body mass index, or tobacco use.
先前已有文献记载盆腔器官脱垂和/或压力性尿失禁患者盆底组织的胶原蛋白含量会降低。然而，对于非支持组织而言，情况尚不清楚。我们旨在比较有无压力性尿失禁的盆腔器官脱垂女性的非支持组织——子宫颈的胶原蛋白含量与无这些问题的女性的子宫颈胶原蛋白含量。
比较了14例有或无压力性尿失禁的盆腔器官脱垂女性与17例无这些情况的对照者的宫颈胶原蛋白含量。标本取自良性妇科疾病手术后。
各组在年龄、产次、体重指数和吸烟情况方面相似。有或无压力性尿失禁的盆腔器官脱垂女性的胶原蛋白含量明显低于对照者（8.10%±3.43% 对12.35%±4.72%，P = 0.0104）。此外，年龄、产次、体重指数或吸烟情况与胶原蛋白含量无显著关系。
无论年龄、产次、体重指数或吸烟情况如何，有或无压力性尿失禁的盆腔器官脱垂女性的宫颈胶原蛋白含量均显著降低。
