Mattisson I, Wirfält E, Johansson U, Gullberg B, Olsson H, Berglund G
Department of Medicine, Surgery and Orthopaedics, Lund University, Malmö University Hospital, SE-205 02 Malmö, Sweden.
Br J Cancer. 2004 Jan 12;90(1):122-7. doi: 10.1038/sj.bjc.6601516.
The objective of this study was to investigate prospectively the associations between intakes of plant foods, fibre and relative fat and risk of breast cancer in a subsample of 11 726 postmenopausal women in the Malmö Diet and Cancer cohort. Data were obtained by an interview-based diet history method, a structured questionnaire, anthropometrical measurements and national and regional cancer registries. During 89 602 person-years of follow-up, 342 incident cases were documented. Cox regression analysis examined breast cancer risks adjusted for potential confounders. High fibre intakes were associated with a lower risk of postmenopausal breast cancer, incidence rate ratio=0.58, 95% CI: 0.40, 0.84, for the highest quintile of fibre intake compared to the lowest quintile. The combination high fibre-low fat had the lowest risk when examining the effect in each cell of cross-classified tertiles of fibre and fat intakes. An interaction (P=0.049) was found between fibre- and fat-tertiles. There was no significant association between breast cancer risk and intakes of any of the plant food subgroups. These findings support the hypothesis that a dietary pattern characterised by high fibre and low fat intakes is associated with a lower risk of postmenopausal breast cancer.
本研究的目的是在前瞻性地调查马尔默饮食与癌症队列中11726名绝经后女性的子样本中，植物性食物、纤维和相对脂肪的摄入量与乳腺癌风险之间的关联。数据通过基于访谈的饮食史方法、结构化问卷、人体测量以及国家和地区癌症登记处获得。在89602人年的随访期间，记录了342例新发病例。Cox回归分析检查了针对潜在混杂因素进行调整后的乳腺癌风险。与纤维摄入量最低的五分位数相比，纤维摄入量最高的五分位数与绝经后乳腺癌风险较低相关，发病率比值=0.58，95%置信区间：0.40，0.84。在检查纤维和脂肪摄入量交叉分类三分位数的每个单元格中的效应时，高纤维-低脂肪组合的风险最低。在纤维和脂肪三分位数之间发现了交互作用（P=0.049）。乳腺癌风险与任何植物性食物亚组的摄入量之间均无显著关联。这些发现支持了这样一种假设，即高纤维和低脂肪摄入特征的饮食模式与绝经后乳腺癌风险较低相关。
