[血管危险因素与阿尔茨海默病]

[Vascular risk factors and Alzheimer's disease].

作者信息

Voisin T, Lugardon S, Balardy L, Vellas B

机构信息

Service de médecine interne et gérontologie clinique, CHU La-Grave Casselardit, 170, avenue de Casselardit, 31300 Toulouse, France.

出版信息

Rev Med Interne. 2003 Oct;24 Suppl 3:288s-291s. doi: 10.1016/s0248-8663(03)80685-9.

DOI:10.1016/s0248-8663(03)80685-9

PMID:14710446

Abstract

BACKGROUND AND OBJECTIVE

Recent epidemiological study and clinico-pathologic data suggest overlaps between Alzheimer disease and cerebrovascular lesions that may magnify the effect of mild Alzheimer disease pathology and promote progression of cognitive decline. There is now strong epidemiologic evidence supporting an association between Alzheimer disease and two major vascular risk factors--blood pressure and diabetes. The major objective of this study is to analyse the impact of vascular risk factors on natural history of Alzheimer's disease.

METHODS

Descriptive analyse of the vascular risk factors on 520 Alzheimer's disease patients issue from the population of the "Programme Hospitalier de Recherche Clinique: "Réseau sur la maladie d'Alzheimer français".

RESULTS

The description of the vascular risk factors in the Alzheimer's disease patients from the "Programme Hospitalier de Recherche Clinique. "Réseau sur la maladie d'Alzheimer Français" was made and the projects and perspectives of analyses based on the longitudinal data were discussed. 45% of subjects have high blood pressure, they were significantly older (p < 0.05), have more frequent impairment of ADLs (p < 0.05), and one-leg balance impairment (p < 0.05). 10% of patients have diabetes and 23.95% hypercholesterolemia.

CONCLUSIONS

The first data on vascular risk factors of the "Programme Hospitalier de Recherche Clinique: "Réseau sur la maladie d'Alzheimer français"" are the first step on comprehension of the impact of vascular risk factors and their traitments on Alzheimer's disease.

摘要

背景与目的

近期的流行病学研究及临床病理数据表明，阿尔茨海默病与脑血管病变之间存在重叠，这可能会放大轻度阿尔茨海默病病理改变的影响，并促进认知功能衰退的进展。目前有强有力的流行病学证据支持阿尔茨海默病与两个主要血管危险因素——血压和糖尿病之间存在关联。本研究的主要目的是分析血管危险因素对阿尔茨海默病自然病程的影响。

方法

对来自“临床研究项目：法国阿尔茨海默病研究网络”人群中的520例阿尔茨海默病患者的血管危险因素进行描述性分析。

结果

对“临床研究项目：法国阿尔茨海默病研究网络”中阿尔茨海默病患者的血管危险因素进行了描述，并讨论了基于纵向数据的分析项目和前景。45%的受试者患有高血压，他们年龄显著更大（p<0.05），日常生活活动能力受损更频繁（p<0.05），且单腿平衡能力受损（p<0.05）。10%的患者患有糖尿病，23.95%的患者患有高胆固醇血症。