van Ijzendoorn Sven C D, Mostov Keith E, Hoekstra Dick
Department of Membrane Cell Biology, University of Groningen, Groningen 9713AV, The Netherlands.
Int Rev Cytol. 2003;232:59-88. doi: 10.1016/s0074-7696(03)32002-9.
Small GTPase rab proteins play an important role in various aspects of membrane traffic, including cargo selection, vesicle budding, vesicle motility, tethering, docking, and fusion. Recent data suggest also that rabs, and their divalent effector proteins, organize organelle subdomains and as such may define functional organelle identity. Most rabs are ubiquitously expressed. However, some rabs are preferentially expressed in epithelial cells where they appear intimately associated with the epithelial-specific transcytotic pathway and/or tight junctions. This review discusses the role of rabs in epithelial membrane transport.
小GTP酶rab蛋白在膜运输的各个方面发挥着重要作用，包括货物选择、囊泡出芽、囊泡运动、拴系、对接和融合。最近的数据还表明，rab蛋白及其二价效应蛋白组织细胞器亚结构域，因此可能定义功能性细胞器身份。大多数rab蛋白在全身广泛表达。然而，一些rab蛋白在上皮细胞中优先表达，它们似乎与上皮特异性转胞吞途径和/或紧密连接密切相关。本文综述了rab蛋白在上皮细胞膜运输中的作用。
