Markgraf Daniel F, Peplowska Karolina, Ungermann Christian
University of Osnabrück, Department of Biology, Biochemistry Section, Barbarastrasse 13, 49076 Osnabrück, Germany.
FEBS Lett. 2007 May 22;581(11):2125-30. doi: 10.1016/j.febslet.2007.01.090. Epub 2007 Feb 12.
Rab GTPases are key proteins that determine organelle identity and operate at the center of fusion reactions. Like Ras, they act as switches that are connected to a diverse network of tethering factors, exchange factors and GTPase activating proteins. Recent studies suggest that Rabs are linked to each other via their effectors, thus coordinating protein transport in the endomembrane system. Within this review, we will focus on selected examples that highlight these issues.
Rab GTP 酶是决定细胞器特性并在融合反应中心发挥作用的关键蛋白质。与 Ras 一样，它们充当连接多种拴系因子、交换因子和 GTP 酶激活蛋白网络的开关。最近的研究表明，Rab 通过其效应器相互连接，从而协调内膜系统中的蛋白质运输。在本综述中，我们将重点关注突出这些问题的特定示例。
