孕期母亲吸烟、胎儿发育与儿童哮喘
Maternal smoking in pregnancy, fetal development, and childhood asthma.
作者信息
Jaakkola Jouni J K, Gissler Mika
机构信息
Institute of Occupational Health, The University of Birmingham, Birmingham, United Kingdom.
出版信息
Am J Public Health. 2004 Jan;94(1):136-40. doi: 10.2105/ajph.94.1.136.
Abstract
OBJECTIVES
We examined the relationships among maternal smoking in pregnancy, fetal development, and the risk of asthma in childhood.
METHODS
We conducted a population-based cohort study, where all 58 841 singleton births were followed for 7 years using nationwide registries.
RESULTS
Maternal smoking increased the risk of asthma (adjusted odds ratio = 1.35; 95% confidence interval = 1.13, 1.62 for high exposure). Low birthweight and preterm delivery increased the risk of asthma at the age of 7, whereas being small for gestational age did not.
CONCLUSIONS
Maternal smoking in pregnancy increases the risk of asthma during the first 7 years of life, and only a small fraction of the effect seems to be mediated through fetal growth.
摘要
目的
我们研究了孕期母亲吸烟、胎儿发育与儿童哮喘风险之间的关系。
方法
我们进行了一项基于人群的队列研究，利用全国性登记系统对所有58841例单胎分娩进行了7年的随访。
结果
母亲吸烟会增加哮喘风险（调整后的优势比=1.35；高暴露水平下95%置信区间为1.13，1.62）。低出生体重和早产会增加7岁时患哮喘的风险，而小于胎龄儿则不会。
结论
孕期母亲吸烟会增加儿童出生后前7年患哮喘的风险，且只有一小部分影响似乎是通过胎儿生长介导的。
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