Gorenkova N A, Nazarenko I V, Volkov A V
Institute of General Reanimatology, Russian Academy of Medical Sciences, Moscow.
Bull Exp Biol Med. 2003 Oct;136(4):348-51. doi: 10.1023/b:bebm.0000010948.51981.fb.
In experiments on rats we studied the effects of antioxidant and membrane-protecting agent mexidol and neuropeptides delta sleep-inducing peptide and oxytocin administered during resuscitation after 12-min clinical death. Individual and combination treatment with these substances accelerated recovery of the neurological status and partially or completely corrected behavioral disorders associated with changes in the emotional and motivational status. Combined administration of mexidol and oxytocin most significantly promoted postresuscitation recovery of functional activity in the central nervous system.
在大鼠实验中，我们研究了抗氧化和膜保护剂美西多芬以及神经肽δ-睡眠诱导肽和催产素在12分钟临床死亡后的复苏过程中给药的效果。这些物质的单独和联合治疗加速了神经状态的恢复，并部分或完全纠正了与情绪和动机状态变化相关的行为障碍。美西多芬和催产素联合给药最显著地促进了中枢神经系统复苏后功能活动的恢复。
