Mering T A
Science Research Institute of the Brain, Russian Academy of Medical Sciences, Moscow.
Neurosci Behav Physiol. 2003 Feb;33(2):133-8. doi: 10.1023/a:1021713629090.
It is demonstrated that even partial damage to the hippocampus is accompanied by impairments to counting time intervals lasting several months (1200-1500 presentations) without alteration of other complex conditioned reflex responses. After treatment with mexidol, which has a wide spectrum of actions, paticularly antioxidant. antihypoxic, and antistress, rats showed a normal process of acquisition of a conditioned reflex to time. Unlike animals of the control group, there was no prolonged period during which there was complete impairment of the mechanism for counting time intervals. Thanks to significant improvements in autonomic processes and emotional-motivational responses, experiments could use a large number of conditioned stimuli. For example, after brain trauma mexidol strengthened compensatory-restorative processes: animals showed accelerated recovery of impaired functions, with decreases in the rate of retrograde degeneration of brain areas directly connected to the damaged parts, phenomena such as Monakow diaschisis were not observed, and so on.
结果表明，即使海马体受到部分损伤，也会伴随持续数月（1200 - 1500次呈现）的时间间隔计数能力受损，而其他复杂条件反射反应并未改变。在用具有广泛作用谱，特别是抗氧化、抗缺氧和抗应激作用的美西律治疗后，大鼠对时间的条件反射习得过程恢复正常。与对照组动物不同，不存在时间间隔计数机制完全受损的延长时期。由于自主神经过程和情绪 - 动机反应有显著改善，实验中可以使用大量的条件刺激。例如，在脑外伤后，美西律加强了代偿 - 恢复过程：动物受损功能恢复加速，与受损部位直接相连的脑区逆行性变性速率降低，未观察到如蒙纳科夫氏远隔机能障碍等现象，等等。
