Denzer Christian, Muche Rainer, Mayer Hermann, Heinze Eberhard, Debatin Klaus-Michael, Wabitsch Martin
Department of Pediatrics, University of Ulm, Germany.
J Pediatr Endocrinol Metab. 2003 Dec;16(9):1225-32. doi: 10.1515/jpem.2003.16.9.1225.
Hyperuricemia is part of the "metabolic syndrome". The aim of this study was to investigate the regulation and role of serum uric acid in the cardiovascular risk factor profile of obese children and adolescents. Serum levels of uric acid and selected risk factors and hormones were determined in 269 children aged 10.0-15.9 years with a BMI >90th percentile (mean 24.0 kg/m2, SD 5.43). Stepwise regression adjusted for age and sex revealed that testosterone (p < 0.0001), BMI (p < 0.0001), systolic blood pressure (p < 0.0017), triglycerides (p < 0.0345) and cholesterol/HDL ratio (p < 0.0393) were positively correlated with serum uric acid and accounted for 42.1% of the variance. Additional regression models with the same set of variables indicated that uric acid contributed significantly to levels of cholesterol/HDL, total cholesterol, BMI and systolic blood pressure, respectively. These results suggest a not yet described impact of androgens in the regulation of serum uric acid in obese children and adolescents. Furthermore, they show that uric acid is a reliable indicator for the "pre-metabolic syndrome" in obese youths.
高尿酸血症是“代谢综合征”的一部分。本研究旨在调查血清尿酸在肥胖儿童和青少年心血管危险因素谱中的调节作用及影响。对269名年龄在10.0 - 15.9岁、BMI>第90百分位数（平均24.0kg/m²，标准差5.43）的儿童测定了血清尿酸水平以及选定的危险因素和激素水平。经年龄和性别校正的逐步回归分析显示，睾酮（p<0.0001）、BMI（p<0.0001）、收缩压（p<0.0017）、甘油三酯（p<0.0345）和胆固醇/高密度脂蛋白比值（p<0.0393）与血清尿酸呈正相关，且解释了42.1%的变异。包含相同变量集的其他回归模型表明，尿酸分别对胆固醇/高密度脂蛋白、总胆固醇、BMI和收缩压水平有显著影响。这些结果提示雄激素在肥胖儿童和青少年血清尿酸调节中的作用尚未见报道。此外，研究表明尿酸是肥胖青少年“代谢综合征前期”的可靠指标。
