Močnik Mirjam, Golob Jančič Sonja, Filipič Martina, Marčun Varda Nataša
Division of Paediatrics, University Clinical Centre Maribor, Maribor, Slovenia.
Front Cardiovasc Med. 2022 Apr 15;9:867428. doi: 10.3389/fcvm.2022.867428. eCollection 2022.
Urate is increasingly recognized as a cardiovascular risk factor. It has been associated with hypertension, metabolic syndrome, obesity, chronic kidney disease and diabetes. Its prognostic role is less clear. The aim of our study was to evaluate the association between serum urate and pulse wave velocity, a measure of arterial stiffness in hypertensive adolescents and young adults.
269 adolescents and young adults with hypertension were included in the study. From all, anthropometric, blood pressure, pulse wave velocity and serum urate measurements were made. Variables were compared between sex, participants with or without obesity and with or without elevated urate.
In multiple regression analysis for urate as dependent variable gender and diastolic pressure were found to be statistically significant. The difference between urate levels were found between boys and girls ( < 0.001), obese and non-obese ( < 0.001); however, pulse wave velocity did not differ between hyper- and eu-uricemic group ( = 0.162).
Associations between urate, gender, diastolic blood pressure and obesity were confirmed, however, no significant associations between pulse wave velocity and urate were detected.
尿酸越来越被认为是一种心血管危险因素。它与高血压、代谢综合征、肥胖、慢性肾病和糖尿病有关。其预后作用尚不清楚。我们研究的目的是评估血清尿酸与脉搏波速度之间的关联，脉搏波速度是衡量高血压青少年和年轻人动脉僵硬度的指标。
269名高血压青少年和年轻人纳入研究。对所有人进行人体测量、血压、脉搏波速度和血清尿酸测量。比较性别、有无肥胖以及有无尿酸升高的参与者之间的变量。
在以尿酸为因变量的多元回归分析中，发现性别和舒张压具有统计学意义。男孩与女孩之间（<0.001）、肥胖与非肥胖者之间（<0.001）的尿酸水平存在差异；然而，高尿酸血症组和正常尿酸血症组之间的脉搏波速度没有差异（=0.162）。
尿酸、性别、舒张压和肥胖之间的关联得到证实，然而，未检测到脉搏波速度与尿酸之间存在显著关联。
