Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, 100730, China.
Department of Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
Sci Rep. 2017 Jul 14;7(1):5456. doi: 10.1038/s41598-017-05751-w.
Hyperuricemia is common in China and the relevance of hyperuricemia and cardiovascular disease (CVD) risk has been highlighted, but to date there has been rarely nation-wide study in China. Here, we aim to estimate the current prevalence of hyperuricemia and evaluate the associations between hyperuricemia and cardiovascular risk factors (CRFs) clustering in a large sample of China adults including a plurality of ethnic minorities. Generally, a nationally representative sample of 22983 adults aged ≥18 years was recruited from 2007 to 2011. Questionnaire data and information on anthropometric characteristics, and laboratory measurements were collected. We define hyperuricemia as SUA ≥416 mmol/L for men and SUA ≥357 mmol/L for women. We found that the prevalence of hyperuricemia was 13.0% (18.5% in men and 8.0% in women). To our estimation, hyperuricemic subjects had higher prevalence rates of CRFs clustering than non-hyperuricemic subjects. Furthermore, there was a dose-response association between the number of CVD risk factors clustering and hyperuricemia. Our study revealed a high prevalence of hyperuricemia and CVD risk factors clustering among Chinese adults, and hyperuricemia was significantly associated with coexistence of more CVD risk factors. Therefore, guidance and effective lifestyle intervention are required to prevent hyperuricemia and CVD risk factors in China.
高尿酸血症在中国很常见，其与心血管疾病（CVD）风险的相关性已得到强调，但迄今为止，中国很少有全国性的研究。在这里，我们旨在评估中国成年人中高尿酸血症的当前流行率，并评估其与心血管危险因素（CRFs）聚类之间的关联，其中包括多个少数民族。一般来说，2007 年至 2011 年期间，从全国范围内招募了 22983 名年龄≥18 岁的成年人作为代表性样本。收集了问卷调查数据以及人体测量特征和实验室测量的信息。我们将高尿酸血症定义为男性 SUA≥416mmol/L 和女性 SUA≥357mmol/L。我们发现高尿酸血症的患病率为 13.0%（男性为 18.5%，女性为 8.0%）。据我们估计，高尿酸血症患者的 CRFs 聚类患病率高于非高尿酸血症患者。此外，CVD 危险因素聚类的数量与高尿酸血症之间存在剂量反应关系。我们的研究揭示了中国成年人中高尿酸血症和 CVD 危险因素聚类的高患病率，并且高尿酸血症与更多 CVD 危险因素的共存明显相关。因此，需要指导和有效的生活方式干预来预防中国的高尿酸血症和 CVD 危险因素。
