Woldeamlak Birhanu, Yirdaw Ketsela, Biadgo Belete
Clinical Chemistry Laboratory, University of Gondar Hospital, Ethiopia.
Department of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Science, University of Gondar, Ethiopia.
EJIFCC. 2019 Oct 11;30(3):325-339. eCollection 2019 Oct.
Hyperuricemia is associated with cardiovascular disease (CVD) that presents in diabetes mellitus patients. Therefore, the aim of this study was to appraise the serum uric acid and its association with CVD risk factors among diabetes mellitus patients.
A cross-sectional study was carried out at the University of Gondar hospital from February to March, 2018. A total of 384 study participants were selected by systematic random sampling technique. Five milliliter blood sample was collected and analyzed using Mindray BS-200E machine. The data was analysed into SPSS version 20. Logistic regression model was used to investigate associated factors. A p-value <0.05 was considered statistically significant.
The prevalence of hyperuricemia among type 2 diabetic patients was 31.5%. The serum uric acid concentration was higher among male (33.1%) compared to female (28.9%). Elevated systolic blood pressure (AOR: 4.4, 95%CI: 2.1-9.3), family history of DM (AOR: 1.5, 95%CI: 1.2-2.5) and BMI ≥ 25 Kg/m (AOR: 1.4, 95%CI: 1.1-3.7) were significantly associated with hyperuricemia. Increased BMI (52.4%), high waist circumference (63.0%) and elevated systolic blood pressure (58.2%) were the major CVD risk factors.
The prevalence of hyperuricemia was high in type 2 diabetes patients. The major predictors of CVD risk factors were elevated systolic blood pressure, family history of DM and BMI ≥ 25 Kg/m which lead to early diagnosis and treatment for hyperuricemia. Lastly, CVD risk factors are essential to reduce the disease among type 2 diabetic patients.
高尿酸血症与糖尿病患者出现的心血管疾病（CVD）相关。因此，本研究的目的是评估糖尿病患者的血清尿酸及其与心血管疾病危险因素的关联。
2018年2月至3月在贡德尔大学医院进行了一项横断面研究。通过系统随机抽样技术共选取了384名研究参与者。采集5毫升血液样本并使用迈瑞BS - 200E机器进行分析。数据录入SPSS 20版进行分析。采用逻辑回归模型研究相关因素。p值<0.05被认为具有统计学意义。
2型糖尿病患者中高尿酸血症的患病率为31.5%。男性的血清尿酸浓度（33.1%）高于女性（28.9%）。收缩压升高（比值比：4.4，95%置信区间：2.1 - 9.3）、糖尿病家族史（比值比：1.5，95%置信区间：1.2 - 2.5）和体重指数≥25千克/米²（比值比：1.4，95%置信区间：1.1 - 3.7）与高尿酸血症显著相关。体重指数增加（52.4%）、高腰围（63.0%）和收缩压升高（58.2%）是主要的心血管疾病危险因素。
2型糖尿病患者中高尿酸血症的患病率较高。心血管疾病危险因素的主要预测因素是收缩压升高、糖尿病家族史和体重指数≥25千克/米²，这有助于高尿酸血症的早期诊断和治疗。最后，心血管疾病危险因素对于降低2型糖尿病患者中的疾病发生率至关重要。
