Rijneveld Anita W, Florquin Sandrine, Speelman Peter, Edwards Carl K, Dinarello Charles A, van der Poll Tom
Academic Medical Center, University of Amsterdam, The Netherlands.
Eur Cytokine Netw. 2003 Oct-Dec;14(4):242-5.
The inhibition of the biological activity of IL-1 by recombinant human IL-1 receptor antagonist (IL-1ra) has been investigated in several, controlled clinical trials. Encouraging results have been reported, in particular in patients with rheumatoid arthritis. In the present study, we investigated the influence of treatment of wild type mice with IL-1ra, which resulted in an incomplete and transient inhibition of IL-1 activity. Treatment with recombinant human IL-1ra resulted in an enhanced bacterial outgrowth in the lungs of BALB/c and C57BL/6 mice early after induction of pneumococcal pneumonia, without influencing survival or the pulmonary inflammatory response. The effect of IL-1ra on the host response to S. pneumoniae pneumonia is modest and transient. The present data, together with the findings in IL-1R*/* mice in earlier work, suggest that IL-1 occupies a role in the pulmonary immune response to S. pneumoniae that is substantially less prominent than that of TNF-alpha.
重组人白细胞介素-1受体拮抗剂（IL-1ra）对白细胞介素-1生物活性的抑制作用已在多项对照临床试验中进行了研究。已有令人鼓舞的结果报道，尤其是在类风湿性关节炎患者中。在本研究中，我们研究了用IL-1ra治疗野生型小鼠的影响，结果导致IL-1活性受到不完全且短暂的抑制。用重组人IL-1ra治疗导致肺炎链球菌肺炎诱导后早期BALB/c和C57BL/6小鼠肺部细菌过度生长，而不影响生存率或肺部炎症反应。IL-1ra对宿主对肺炎链球菌肺炎反应的影响是适度且短暂的。目前的数据，连同早期工作中在IL-1R*/*小鼠中的发现，表明IL-1在对肺炎链球菌的肺部免疫反应中所起的作用远不如TNF-α显著。
