Mandel Silvia, Reznichenko Lydia, Amit Tamar, Youdim Moussa B H
Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research, Technion-Faculty of Medicine, Haifa 31096, Israel.
Neurotox Res. 2003;5(6):419-24. doi: 10.1007/BF03033171.
Our recent studies have demonstrated that green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) exerts neuroprotective/neurorescue effects against B-amyloid toxicity and protects neuronal cells from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridinium ion (MPP+) and 6-hydroxydopamine in vitro, or from N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- (MPTP-) induced nigral dopaminergic neuronal loss in mice. In the present study, we report that EGCG (0.1 and 1 microM) significantly protects rat pheochromocytoma PC12 cells from apoptosis induced by serum support withdrawal, suggesting that EGCG may play a role in the growth of PC12 cells, where it stimulates survival-promoting pathways.
我们最近的研究表明，绿茶多酚（-）-表没食子儿茶素-3-没食子酸酯（EGCG）对β-淀粉样蛋白毒性具有神经保护/神经挽救作用，并在体外保护神经元细胞免受1-甲基-4-苯基-1,2,3,6-四氢吡啶离子（MPP +）和6-羟基多巴胺的侵害，或免受N-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP-）诱导的小鼠黑质多巴胺能神经元损失。在本研究中，我们报告EGCG（0.1和1 microM）可显著保护大鼠嗜铬细胞瘤PC12细胞免受血清支持撤除诱导的凋亡，这表明EGCG可能在PC12细胞的生长中发挥作用，在其中它刺激促进存活的途径。
