Carrera-Juliá Sandra, Moreno Mari Luz, Barrios Carlos, de la Rubia Ortí Jose Enrique, Drehmer Eraci
Doctoral Degree's School, Catholic University of Valencia "San Vicente Mártir", Valencia, Spain.
Department of Nutrition and Dietetics, Catholic University of Valencia "San Vicente Mártir", Valencia, Spain.
Front Physiol. 2020 Feb 6;11:63. doi: 10.3389/fphys.2020.00063. eCollection 2020.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that produces a selective loss of the motor neurons of the spinal cord, brain stem and motor cortex. Oxidative stress (OS) associated with mitochondrial dysfunction and the deterioration of the electron transport chain has been shown to be a factor that contributes to neurodegeneration and plays a potential role in the pathogenesis of ALS. The regions of the central nervous system affected have high levels of reactive oxygen species (ROS) and reduced antioxidant defenses. Scientific studies propose treatment with antioxidants to combat the characteristic OS and the regeneration of nicotinamide adenine dinucleotide (NAD) levels by the use of precursors. This review examines the possible roles of nicotinamide riboside and pterostilbene as therapeutic strategies in ALS.
肌萎缩侧索硬化症（ALS）是一种神经退行性疾病，会导致脊髓、脑干和运动皮层的运动神经元选择性丧失。与线粒体功能障碍和电子传递链退化相关的氧化应激（OS）已被证明是导致神经退行性变的一个因素，并在ALS的发病机制中发挥潜在作用。受影响的中枢神经系统区域具有高水平的活性氧（ROS）且抗氧化防御能力降低。科学研究提出使用抗氧化剂进行治疗，以对抗特征性的氧化应激，并通过使用前体来恢复烟酰胺腺嘌呤二核苷酸（NAD）水平。本综述探讨了烟酰胺核糖和紫檀芪作为ALS治疗策略的可能作用。
