Skidmore Paula M L, Hardy Rebecca J, Kuh Diana J, Langenberg Claudia, Wadsworth Michael E J
MRC National Survey of Health and Development, University College London Medical School, Department of Epidemiology and Public Health, London, UK.
Arterioscler Thromb Vasc Biol. 2004 Mar;24(3):588-94. doi: 10.1161/01.ATV.0000116692.85043.ef. Epub 2004 Jan 8.
To investigate the association between birth weight and lipid levels in a 53-year-old birth cohort from England, Scotland, and Wales.
Lipid levels were obtained from nonfasting blood samples, collected at the most recent follow-up of the MRC National Survey of Health and Development, for 2559 men and women. Regression models indicated that in men, a 1-kg increase in birth weight was associated with a 0.13-mmol/L decrease (95% CI: -0.23, -0.01) in total cholesterol at age 53 years (P=0.03), compared with a 0.02-mmol/L (95% CI: -0.11, 0.15) increase in women and a 0.06-mmol/L (95% CI: -0.15, 0.02) decrease in men and women combined. Adjustment for current height and body mass index (BMI) in men reduced the size of the relationship, with height being responsible for the reduction. Adult height and height at 2 and 4 years were significantly associated with total cholesterol in men and in men and women combined. The negative association between total cholesterol and birth weight was strongest among men with high BMI at age 53 years (P=0.03 for test for interaction between birth weight and BMI). There was no significant association between birth weight and LDL or HDL cholesterol in men or women before adjustment, but there was a positive association with HDL in women. When both sexes were analyzed together, an association was seen after adjustment for current body size. No confounding of these findings with social class was observed in this study.
Our results suggest that the small effect of birth weight on lipid levels at age 53 years has a limited public health impact. The findings suggest that childhood height growth may be more important than prenatal growth.
研究来自英格兰、苏格兰和威尔士的一个53岁出生队列中出生体重与血脂水平之间的关联。
从英国医学研究委员会全国健康与发展调查最近一次随访时采集的非空腹血样中获取了2559名男性和女性的血脂水平。回归模型表明，在男性中，出生体重每增加1千克，53岁时总胆固醇水平降低0.13毫摩尔/升（95%置信区间：-0.23，-0.01）（P=0.03），而女性则增加0.02毫摩尔/升（95%置信区间：-0.11，0.15），男性和女性综合起来降低0.06毫摩尔/升（95%置信区间：-0.15，0.02）。对男性当前身高和体重指数（BMI）进行调整后，这种关联的强度有所降低，身高是导致这种降低的原因。成年身高以及2岁和4岁时的身高与男性以及男性和女性综合起来的总胆固醇水平显著相关。在53岁时BMI较高的男性中，总胆固醇与出生体重之间的负相关最强（出生体重与BMI之间的交互作用检验P=0.03）。在调整之前，出生体重与男性或女性的低密度脂蛋白或高密度脂蛋白胆固醇之间没有显著关联，但与女性的高密度脂蛋白有正相关。当对两性进行综合分析时，在对当前身体大小进行调整后发现了一种关联。在本研究中未观察到这些结果与社会阶层之间存在混杂情况。
我们的结果表明，出生体重对53岁时血脂水平的微小影响对公共卫生的影响有限。这些发现表明，儿童期身高增长可能比出生前生长更为重要。
