Horta Bernardo L, Victora Cesar G, Lima Rosângela C, Post Paulo
Post-Graduate Programme in Epidemiology, Universidade Federal de Pelotas, Pelotas, RS, Brazil.
Acta Paediatr. 2009 Jun;98(6):1024-8. doi: 10.1111/j.1651-2227.2009.01247.x.
To assess the effect of weight gain in childhood on blood lipid levels in adolescence.
A population-based birth cohort carried out in Pelotas, Southern Brazil. All newborns in the city's hospitals were enrolled in 1982. The subjects have been followed up for several times in childhood. At age 18, 79% of all males were followed, and 2083 blood samples were available. Adjusted analyses controlled for household assets index, family income, parental schooling at birth, maternal smoking during pregnancy and breastfeeding duration.
Birth weight for gestational age and weight gain in the first 20 months was not associated with blood lipid levels in adolescence. On the other hand, those subjects whose weight gain from 20 to 42 months of age was faster than that predicted from birth weight and weight-for-age z-score at the mean age of 20 months had lower high-density lipoprotein cholesterol (HDL) cholesterol [-0.78(95% confidence interval: -1.28; -0.29)] and higher very low-density lipoprotein cholesterol (VLDL) and low-density lipoprotein cholesterol (LDL)/HDL ratio in adolescence. After controlling for current body mass index (BMI), the regression coefficient for HDL cholesterol decreased from -0.78 mg/dL to -0.29 mg/dL (95% confidence interval: -1.00 to 0.05).
Weight gain from 2 to 4 years is related to an atherogenic lipid profile in adolescence and this association is mediated by current BMI.
评估儿童期体重增加对青少年血脂水平的影响。
在巴西南部的佩洛塔斯进行了一项基于人群的出生队列研究。1982年该市医院的所有新生儿均被纳入研究。这些受试者在儿童期接受了多次随访。18岁时，对所有男性中的79%进行了随访，共获得2083份血样。校正分析控制了家庭资产指数、家庭收入、出生时父母的受教育程度、孕期母亲吸烟情况和母乳喂养持续时间。
出生体重与胎龄以及出生后前20个月的体重增加与青少年血脂水平无关。另一方面，那些在20至42个月龄时体重增加速度快于根据出生体重和20个月龄时的年龄别体重Z评分预测值的受试者，其青少年期高密度脂蛋白胆固醇（HDL）水平较低[-0.78（95%置信区间：-1.28；-0.29）]，极低密度脂蛋白胆固醇（VLDL）和低密度脂蛋白胆固醇（LDL）/HDL比值较高。在控制了当前体重指数（BMI）后，HDL胆固醇的回归系数从-0.78mg/dL降至-0.29mg/dL（95%置信区间：-1.00至0.05）。
2至4岁时的体重增加与青少年期致动脉粥样硬化的血脂谱有关，且这种关联由当前BMI介导。
