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希腊成年人血脂状况及管理及其与社会人口统计学、生活方式和饮食因素的关系:阿提卡研究。希腊的血脂分布情况。

Status and management of blood lipids in Greek adults and their relation to socio-demographic, lifestyle and dietary factors: the ATTICA Study. Blood lipids distribution in Greece.

作者信息

Panagiotakos Demosthenes B, Pitsavos Christos, Chrysohoou Christina, Skoumas John, Stefanadis Christodoulos

机构信息

First Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece.

出版信息

Atherosclerosis. 2004 Apr;173(2):353-61. doi: 10.1016/j.atherosclerosis.2003.12.031.

Abstract

OBJECTIVE

In this work, we assessed the status and management of blood lipids in a sample of cardiovascular disease free adult men and women from Greece. We also evaluated the effect of several socio-demographic, dietary and lifestyle habits on lipid levels.

METHODS

The ATTICA Study is a population-based cohort that has randomly enrolled 1128 men and 1154 women (aged >18 years old), stratified by age-gender, from the greater area of Athens, during 2001-2002. Adherence to Mediterranean diet was assessed through a diet score that was based on a validated food-frequency questionnaire.

RESULTS

Forty-six percent of men and 40% of women had total serum cholesterol levels >200mg/dl. Of them, 40% of men and 30% of women were unaware of their condition. Twenty-one percent of men and 7% of women had HDL-cholesterol levels <35 mg/dl. Twenty-eight percent of men and 13% of women had triglyceride levels >150 mg/dl. Fifteen percent of men and 12% of women had LDL-cholesterol levels >160 mg/dl and 52% of men and 48% of women had LDL >130 mg/dl. Of those who had known blood lipid abnormalities, 36% of men and 33% of women followed a dietary medication, 31% of men and 20% of women were receiving a pharmaceutical treatment (mainly statin) and the rest were untreated. Participants who adopted the Mediterranean diet and received statin, had on average 9% lower total cholesterol (P = 0.04), 19% lower LDL-cholesterol levels (P = 0.02) and 32% lower oxidized LDL-cholesterol levels (P < 0.001) compared to those who were untreated and adopted a Westernized diet.

CONCLUSIONS

We could speculate that about 3 million Greek adults had high total cholesterol levels. Adverse findings were also observed regarding the other investigated blood lipids. Mediterranean diet could be a complimentary mean to pharmaceutical treatment in reducing blood lipids.

摘要

目的

在本研究中,我们评估了希腊无心血管疾病的成年男性和女性样本中的血脂状况及管理情况。我们还评估了几种社会人口统计学、饮食和生活方式习惯对血脂水平的影响。

方法

阿提卡研究是一项基于人群的队列研究,在2001年至2002年期间,从雅典大区按年龄和性别分层随机招募了1128名男性和1154名女性(年龄>18岁)。通过基于经过验证的食物频率问卷的饮食评分来评估对地中海饮食的依从性。

结果

46%的男性和40%的女性血清总胆固醇水平>200mg/dl。其中,40%的男性和30%的女性未意识到自己的病情。21%的男性和7%的女性高密度脂蛋白胆固醇水平<35mg/dl。28%的男性和13%的女性甘油三酯水平>150mg/dl。15%的男性和12%的女性低密度脂蛋白胆固醇水平>160mg/dl,52%的男性和48%的女性低密度脂蛋白>130mg/dl。在已知血脂异常的人群中,36%的男性和33%的女性遵循饮食疗法,31%的男性和20%的女性接受药物治疗(主要是他汀类药物),其余未接受治疗。与未接受治疗且采用西式饮食的参与者相比,采用地中海饮食并接受他汀类药物治疗的参与者总胆固醇平均低9%(P = 0.04),低密度脂蛋白胆固醇水平低19%(P = 0.02),氧化低密度脂蛋白胆固醇水平低32%(P < 0.001)。

结论

我们可以推测,约300万希腊成年人总胆固醇水平较高。在其他研究的血脂方面也观察到了不良结果。地中海饮食可能是药物治疗降低血脂的一种辅助手段。

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