Hussein M A, George R, Rybicki L, Karam M A
Cleveland Clinic Myeloma Research Program, 9500 Euclid Ave R35, Cleveland, OH 44195, USA.
Med Oncol. 2003;20(4):349-54. doi: 10.1385/MO:20:4:349.
Plasma cell dyscrasias are clonal proliferations and accumulations of plasma cells. The etiology of monoclonal neoplasms still remains elusive. A direct correlation between a history of trauma and the development of plasma cell dyscrasias has not been established. Two recent case reports have described plasmacytomas that were diagnosed in patients who suffered injury at the site of plasma cell neoplasms. We report a series of eight patients who stated a history of trauma to the site where plasma cell neoplasms were later diagnosed. The duration from the date of injury to diagnosis ranged from 2 mo to 20 yr. The M:F ratio was 6:2. The median age was 52 (28-75). Multiple myeloma was confirmed in six patients and plasmacytoma without systemic disease in the other two patients. All eight patients had a kappa monoclonal plasma cell population, and all but one had a detectable peripheral kappa light chain. All patients presented with persistent discomfort at the site where they had experienced trauma. Even though this article does not establish a relationship between trauma, and the development of plasma cell dyscrasia, persistent discomfort at a previous trauma site warrants a complete evaluation and consideration for possible plasma cell dyscrasias.
浆细胞异常增殖症是浆细胞的克隆性增殖和积聚。单克隆肿瘤的病因仍然不明。创伤史与浆细胞异常增殖症的发生之间尚未建立直接关联。最近有两份病例报告描述了在浆细胞瘤部位受伤的患者被诊断出患有浆细胞瘤。我们报告了一系列8例患者，他们均称在后来被诊断出浆细胞瘤的部位有过创伤史。从受伤日期到诊断的时间间隔为2个月至20年。男女比例为6:2。中位年龄为52岁（28 - 75岁）。6例患者确诊为多发性骨髓瘤，另外2例患者确诊为无全身疾病的浆细胞瘤。所有8例患者均有κ单克隆浆细胞群，除1例患者外，其余患者外周血κ轻链均可检测到。所有患者在创伤部位均有持续不适。尽管本文未确立创伤与浆细胞异常增殖症发生之间的关系，但既往创伤部位的持续不适仍需进行全面评估，并考虑是否存在浆细胞异常增殖症。
