Chiyoda Nobuhiro, Kobayashi Etsuko, Okubo Yasushi, Suwazono Yasushi, Kido Teruhiko, Nogawa Koji
Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Japan.
Biol Trace Elem Res. 2003 Winter;96(1-3):9-20. doi: 10.1385/BTER:96:1-3:9.
We investigated a dose-response relationship between renal dysfunction and lifetime cadmium intake in individual subjects using logistic regression analysis and calculated the allowable level of lifetime cadmium intake among the inhabitants of the Jinzu River basin. From the participants of 1967 and 1968 health examinations, target subjects in whose hamlet the cadmium concentration in rice was known and whose history of residence was also known were selected. Cadmium concentrations in rice from data analyzed by the Toyama Prefecture from 1971 to 1976 were used. The urinary examination was done by semiquantitative determination of protein and glucose. All odds ratios for lifetime cadmium intake obtained from logistic regression analysis were more than 1 in both males and females who had resided in their current hamlet since birth with and without subjects who moved from nonpolluted areas and with or without the control group. The allowable levels of lifetime cadmium intake were calculated by substituting the abnormality rates of urinary findings of the controls 40, 50, 60, and 70 yr old into the logistic regression formula. The allowable levels of lifetime cadmium intake were less than 1.58 g for both sexes and each age group using proteinuria with glucosuria measurements.
我们使用逻辑回归分析研究了个体受试者肾功能障碍与终生镉摄入量之间的剂量反应关系，并计算了神通川流域居民终生镉摄入量的允许水平。从1967年和1968年健康检查的参与者中，选择了其所在村庄大米镉浓度已知且居住史也已知的目标受试者。使用了富山县1971年至1976年分析数据中的大米镉浓度。尿液检查通过蛋白质和葡萄糖的半定量测定进行。从逻辑回归分析中获得的终生镉摄入量的所有比值比在自出生以来一直居住在其当前村庄的男性和女性中均大于1，无论有无从无污染地区迁入的受试者以及有无对照组。通过将40、50、60和70岁对照组尿液检查异常率代入逻辑回归公式，计算出终生镉摄入量的允许水平。使用蛋白尿伴糖尿测量法，男女各年龄组的终生镉摄入量允许水平均低于(1.58g)。
