Kobayashi Etsuko, Suwazono Yasushi, Dochi Mirei, Honda Ryumon, Kido Teruhiko
Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuohku, Chiba 260-8670, Japan.
Biol Trace Elem Res. 2009 Mar;127(3):257-68. doi: 10.1007/s12011-008-8239-z. Epub 2008 Nov 1.
The aim of this study was to clarify whether consumption of cadmium (Cd)-polluted rice or Jinzu River water exerted any influence on the occurrence of renal tubular dysfunction and/or Itai-itai disease. From the participants of health examinations conducted in 1967 and 1968, 3,078 subjects who had resided for >30 years in the present hamlet and were aged >50 years were selected as the target population and were divided according to their residence in 55 hamlets. In a multiple regression analysis, the regression coefficients between rice-Cd concentration and prevalence of abnormal urinary findings (proteinuria, glucosuria, or proteinuria with glucosuria) or patients with Itai-itai disease were statistically significant between both sexes. The correlation between the prevalence of users of Jinzu River water and the occurrence of glucosuria in men as well as abnormal urinary findings in women was not statistically significant. We surmise that eating Cd-polluted rice and drinking and/or cooking with Jinzu River water influenced the occurrence of Itai-itai disease. The occurrence of renal tubular dysfunction is likely to have also been influenced by both factors, with eating Cd-polluted rice having a greater impact on the occurrence of renal tubular dysfunction as compared to drinking and/or cooking with Jinzu River water.
本研究的目的是阐明食用镉（Cd）污染的大米或饮用仁井田河水是否会对肾小管功能障碍和/或痛痛病的发生产生任何影响。从1967年和1968年进行的健康检查参与者中，选择了3078名在当前村庄居住超过30年且年龄超过50岁的受试者作为目标人群，并根据他们在55个村庄的居住情况进行了划分。在多元回归分析中，大米镉浓度与异常尿液检查结果（蛋白尿、糖尿或蛋白尿合并糖尿）患病率或痛痛病患者之间的回归系数在两性中均具有统计学意义。仁井田河水使用者的患病率与男性糖尿的发生以及女性异常尿液检查结果之间的相关性无统计学意义。我们推测，食用镉污染的大米以及用仁井田河水饮用和/或烹饪会影响痛痛病的发生。肾小管功能障碍的发生可能也受到了这两个因素的影响，与用仁井田河水饮用和/或烹饪相比，食用镉污染的大米对肾小管功能障碍的发生影响更大。
