Sakamoto S, Yoshino H, Shirahata Y, Shimodairo K, Okamoto R
Medical Research Institute, Tokyo Medical and Dental University, Japan.
Am J Chin Med. 1992;20(3-4):313-7. doi: 10.1142/S0192415X92000333.
Kuei-chih-fu-ling-wan (Keishi-bukuryo-gan; KBG), a traditional Chinese herbal remedy contains five components: bark of Cinnamomum cassia Bl. (Lauraceae), root of Paeonia lactiflora Pall. (Paeoniaceae), seed of Prunus persica Batsch. or P. persiba Batsch.var.davidiana Maxim. (Rosaceae), carpophores of Poria cocos Wolf. (Polyporaceae), and root bark of Paeonia suffruticosa Andr. (Paeoniaceae). This prescription has been frequently used in the treatment of gynecological disorders such as hypermenorrhea, dysmenorrhea and sterility. We previously reported that KBG might act as a LH-RH antagonist and a weak anti-estrogen on the uterine DNA synthesis in immature rats. In the present study, we investigated the effects of KBG on 110 premenopausal patients with uterine myomas. Clinical symptoms of hypermenorrhea and dysmenorrhea were improved in more than 90% of the cases with shrinking of uterine myomas in roughly 60% of the cases.
桂枝茯苓丸（Keishi-bukuryo-gan；KBG）是一种传统的中药方剂，包含五种成分：肉桂（樟科）、白芍（芍药科）、桃仁（蔷薇科）、茯苓（多孔菌科）和牡丹皮（芍药科）。该方剂常用于治疗妇科疾病，如月经过多、痛经和不孕。我们之前报道过，KBG可能作为促黄体生成素释放激素（LH-RH）拮抗剂和弱抗雌激素，对未成熟大鼠子宫DNA合成产生作用。在本研究中，我们调查了KBG对110例绝经前子宫肌瘤患者的影响。超过90%的病例中月经过多和痛经的临床症状得到改善，约60%的病例子宫肌瘤缩小。
