Tsang Owen Tak-Yin, Chau Tai-Nin, Choi Kin-Wing, Tso Eugene Yuk-Keung, Lim Wilina, Chiu Ming-Chi, Tong Wing-Lok, Lee Po-Oi, Lam Bosco Hoi Shiu, Ng Tak-Keung, Lai Jak-Yiu, Yu Wai-Cho, Lai Sik-To
Princess Margaret Hospital, Hong Kong.
Emerg Infect Dis. 2003 Nov;9(11):1381-7. doi: 10.3201/eid0911.030400.
Severe acute respiratory syndrome (SARS) has caused a major epidemic worldwide. A novel coronavirus is deemed to be the causative agent. Early diagnosis can be made with reverse transcriptase-polymerase chain reaction (RT-PCR) of nasopharyngeal aspirate samples. We compared symptoms of 156 SARS-positive and 62 SARS-negative patients in Hong Kong; SARS was confirmed by RT-PCR. The RT-PCR-positive patients had significantly more shortness of breath, a lower lymphocyte count, and a lower lactate dehydrogenase level; they were also more likely to have bilateral and multifocal chest radiograph involvement, to be admitted to intensive care, to need mechanical ventilation, and to have higher mortality rates. By multivariate analysis, positive RT-PCR on nasopharyngeal aspirate samples was an independent predictor of death within 30 days.
严重急性呼吸综合征（SARS）已在全球范围内引发了一场重大疫情。一种新型冠状病毒被认为是病原体。通过对鼻咽抽吸物样本进行逆转录聚合酶链反应（RT-PCR）可进行早期诊断。我们比较了香港156例SARS阳性患者和62例SARS阴性患者的症状；SARS通过RT-PCR确诊。RT-PCR阳性患者出现气短的情况明显更多，淋巴细胞计数更低，乳酸脱氢酶水平更低；他们也更有可能出现双侧和多灶性胸部X光片受累，被收入重症监护病房，需要机械通气，且死亡率更高。通过多变量分析，鼻咽抽吸物样本RT-PCR呈阳性是30天内死亡的独立预测因素。
