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本文引用的文献

1
Life-threatening infantile diarrhea from fluoroquinolone-resistant Salmonella enterica typhimurium with mutations in both gyrA and parC.由同时具有gyrA和parC突变的耐氟喹诺酮鼠伤寒沙门氏菌引起的危及生命的婴儿腹泻。
Emerg Infect Dis. 2003 Feb;9(2):255-7. doi: 10.3201/eid0902.020185.
2
Is it time to change fluoroquinolone breakpoints for Salmonella spp.?是时候改变沙门氏菌属的氟喹诺酮类药物断点了吗？
Antimicrob Agents Chemother. 2003 Feb;47(2):827-9. doi: 10.1128/AAC.47.2.827-829.2003.
3
Fluoroquinolone resistance in Salmonella serovars isolated from humans and food animals.从人类和食用动物中分离出的沙门氏菌血清型对氟喹诺酮类药物的耐药性。
FEMS Microbiol Rev. 2002 Mar;26(1):3-16. doi: 10.1111/j.1574-6976.2002.tb00596.x.
4
Mechanism of plasmid-mediated quinolone resistance.质粒介导的喹诺酮耐药机制。
Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5638-42. doi: 10.1073/pnas.082092899. Epub 2002 Apr 9.
5
Resistance to ciprofloxacin in non-typhoidal salmonellas from humans in England and Wales-the current situation.英格兰和威尔士人类非伤寒沙门氏菌对环丙沙星的耐药性——现状
Clin Microbiol Infect. 1999 Mar;5(3):130-134. doi: 10.1111/j.1469-0691.1999.tb00525.x.
6
A soxRS-constitutive mutation contributing to antibiotic resistance in a clinical isolate of Salmonella enterica (Serovar typhimurium).一种导致肠炎沙门氏菌（鼠伤寒血清型）临床分离株产生抗生素抗性的soxRS组成型突变。
Antimicrob Agents Chemother. 2001 Jan;45(1):38-43. doi: 10.1128/AAC.45.1.38-43.2001.
7
Antibiotic resistance in salmonellae isolated from humans and animals in France: comparative data from 1994 and 1997.法国人和动物源沙门氏菌的抗生素耐药性：1994年和1997年的比较数据。
J Antimicrob Chemother. 2000 Dec;46(6):965-71. doi: 10.1093/jac/46.6.965.
8
Evidence for an efflux pump mediating multiple antibiotic resistance in Salmonella enterica serovar Typhimurium.鼠伤寒沙门氏菌中存在一种介导多重抗生素耐药性的外排泵的证据。
Antimicrob Agents Chemother. 2000 Nov;44(11):3118-21. doi: 10.1128/AAC.44.11.3118-3121.2000.
9
Origins and consequences of antimicrobial-resistant nontyphoidal Salmonella: implications for the use of fluoroquinolones in food animals.耐抗菌药物非伤寒沙门氏菌的起源与后果：对氟喹诺酮类药物在食用动物中使用的影响
Microb Drug Resist. 2000 Spring;6(1):77-83. doi: 10.1089/mdr.2000.6.77.
10
Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluoroquinolone antibacterial levofloxacin.铜绿假单胞菌外排泵抑制剂可增强氟喹诺酮类抗菌药左氧氟沙星的活性。
J Med Chem. 1999 Dec 2;42(24):4928-31. doi: 10.1021/jm9904598.

人类鼠伤寒沙门氏菌分离株中与氟喹诺酮耐药性相关的GyrA、GyrB和ParC突变。

Fluoroquinolone resistance linked to GyrA, GyrB, and ParC mutations in Salmonella enterica typhimurium isolates in humans.

作者信息

Casin Isabelle, Breuil Jacques, Darchis Jean Pierre, Guelpa Claire, Collatz Ekkehard

机构信息

Hõpital Saint-Louis, Université Paris VII, Paris, France.

出版信息

Emerg Infect Dis. 2003 Nov;9(11):1455-7. doi: 10.3201/eid0911.030317.

DOI:10.3201/eid0911.030317
PMID:14718091
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3035553/
Abstract

We report two cases of infection with clonally unrelated, high-level ciprofloxacin-resistant, b-lactamase-producing strains of Salmonella enterica Typhimurium. Resistance was caused by four topoisomerase mutations, in GyrA, GyrB, and ParC and increased drug efflux. Ciprofloxacin treatment failed in one case. In the second case, reduced susceptibility to third-generation cephalosporins occurred after initial treatment with these drugs and may explain the treatment failure with ceftriaxone.

摘要

我们报告了两例感染鼠伤寒沙门氏菌的病例，这两例感染由克隆无关、对环丙沙星高度耐药且产β-内酰胺酶的菌株引起。耐药性是由GyrA、GyrB和ParC中的四个拓扑异构酶突变以及药物外排增加导致的。环丙沙星治疗在其中一例中失败。在第二例中，最初使用第三代头孢菌素治疗后出现了对这些药物的敏感性降低，这可能解释了头孢曲松治疗失败的原因。