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监测卡氏肺孢子虫肺炎的非侵入性方法。

Noninvasive method for monitoring Pneumocystis carinii pneumonia.

作者信息

Linke Michael J, Rebholz Sandy, Collins Margaret, Tanaka Reiko, Cushion Melanie T

机构信息

Veterans Affairs Medical Center, Cincinnati, Ohio, USA.

出版信息

Emerg Infect Dis. 2003 Dec;9(12):1613-6. doi: 10.3201/eid0912.030270.

DOI:10.3201/eid0912.030270
PMID:14720405
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3034349/
Abstract

The progression of Pneumocystis carinii pneumonia was temporally monitored and quantified by real-time polymerase chain reaction of P. carinii-specific DNA in oral swabs and lung homogenates from infected rats. DNA levels correlated with the number of P. carinii organisms in the rats' lungs, as enumerated by microscopic methods. This report is the first of a noninvasive, antemortem method that can be used to monitor infection in a host over time.

摘要

通过对感染大鼠口腔拭子和肺匀浆中卡氏肺孢子虫特异性DNA进行实时聚合酶链反应，对卡氏肺孢子虫肺炎的进展进行了时间上的监测和定量。DNA水平与通过显微镜方法计数的大鼠肺中卡氏肺孢子虫生物体数量相关。本报告首次介绍了一种可用于随时间监测宿主感染情况的非侵入性生前方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56e4/3034349/11b3ba2f4f54/03-0270-F.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56e4/3034349/11b3ba2f4f54/03-0270-F.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56e4/3034349/11b3ba2f4f54/03-0270-F.jpg

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本文引用的文献

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Quantitative real-time PCR method for detection of B-lymphocyte monoclonality by comparison of kappa and lambda immunoglobulin light chain expression.通过比较kappa和lambda免疫球蛋白轻链表达来检测B淋巴细胞单克隆性的定量实时PCR方法。
Clin Chem. 2003 Jan;49(1):51-9. doi: 10.1373/49.1.51.
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Pneumocystis carinii pneumonia in patients in the developing world who have acquired immunodeficiency syndrome.发展中国家患有获得性免疫缺陷综合征患者的卡氏肺孢子虫肺炎。
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通过肺印片涂片（触片）对两名婴儿尸检标本中的肺孢子菌原发性感染进行诊断。
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Echinocandin treatment of pneumocystis pneumonia in rodent models depletes cysts leaving trophic burdens that cannot transmit the infection.棘白菌素类药物治疗啮齿动物模型中的肺孢子菌肺炎会耗尽包囊，留下无法传播感染的滋养负荷。
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Real-time PCR in clinical microbiology: applications for routine laboratory testing.临床微生物学中的实时聚合酶链反应：在常规实验室检测中的应用
Clin Microbiol Rev. 2006 Jan;19(1):165-256. doi: 10.1128/CMR.19.1.165-256.2006.
通过聚合酶链反应（PCR）和口腔拭子证明新生大鼠早期感染卡氏肺孢子虫。
Eukaryot Cell. 2002 Jun;1(3):414-9. doi: 10.1128/EC.1.3.414-419.2002.
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