家族性地中海热儿科患者特应性疾病患病率降低

Decreased prevalence of atopy in paediatric patients with familial Mediterranean fever.

作者信息

Sackesen C, Bakkaloglu A, Sekerel B E, Ozaltin F, Besbas N, Yilmaz E, Adalioglu G, Ozen S

机构信息

Hacettepe University Medical Faculty, Paediatric Allergy and Asthma Unit, Ankara, Turkey.

出版信息

Ann Rheum Dis. 2004 Feb;63(2):187-90. doi: 10.1136/ard.2003.007013.

DOI:10.1136/ard.2003.007013

PMID:14722209

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1754884/

Abstract

BACKGROUND

A number of inflammatory diseases, including familial Mediterranean fever (FMF), have been shown to be driven by a strongly dominated Th1 response, whereas the pathogenesis of atopic diseases is associated with a Th2 response.

OBJECTIVE

Because dominance of interferon gamma has the potential of inhibiting Th2 type responses-that is, development of allergic disorders, to investigate whether FMF, or mutations of the MEFV gene, have an effect on allergic diseases and atopy that are associated with an increased Th2 activity.

METHOD

Sixty children with FMF were questioned about allergic diseases such as asthma, allergic rhinitis, and atopic dermatitis, as were first degree relatives, using the ISAAC Study phase II questionnaire. The ISAAC Study phase II was performed in a similar ethnic group recruited from central Anatolia among 3041 children. The same skin prick test panel used for the ISAAC Study was used to investigate the presence of atopy in patients with FMF and included common allergens.

RESULTS

The prevalences of doctor diagnosed asthma, allergic rhinitis, and eczema were 3.3, 1.7, and 3.3%, respectively, in children with FMF, whereas the corresponding prevalences in the ISAAC study were 6.9, 8.2, and 2.2%, respectively. Only the prevalence of allergic rhinitis was significantly different between the two groups (p<0.001). The prevalence of atopy in these patients with FMF (4/60 (7%)) was significantly lower than in the children of the population based study (20.6%) (p<0.001).

CONCLUSION

Family Mediterranean fever seems to be protective against development of atopic sensitisation and allergic rhinitis.

摘要

背景

包括家族性地中海热（FMF）在内的多种炎症性疾病已被证明由强烈占主导地位的Th1反应驱动，而异位性疾病的发病机制与Th2反应相关。

目的

由于干扰素γ的优势有抑制Th2型反应的潜力，即过敏性疾病的发展，因此研究FMF或MEFV基因突变是否对与Th2活性增加相关的过敏性疾病和特应性有影响。

方法

使用国际儿童哮喘和过敏研究（ISAAC）第二阶段问卷，对60名FMF患儿及其一级亲属询问哮喘、过敏性鼻炎和特应性皮炎等过敏性疾病情况。ISAAC第二阶段研究在从安纳托利亚中部招募的3041名儿童组成的类似种族群体中进行。用于ISAAC研究的相同皮肤点刺试验面板用于调查FMF患者的特应性情况，其中包括常见变应原。

结果

FMF患儿中医生诊断的哮喘、过敏性鼻炎和湿疹的患病率分别为3.3%、1.7%和3.3%，而ISAAC研究中的相应患病率分别为6.9%、8.2%和2.2%。两组之间仅过敏性鼻炎的患病率有显著差异（p<0.001）。这些FMF患者的特应性患病率（4/60（7%））显著低于基于人群研究中的儿童（20.6%）（p<0.001）。