Xiong Yumei, Miyamoto Norimasa, Shibata Kenji, Valasek Mark A, Motoike Toshiyuki, Kedzierski Rafal M, Yanagisawa Masashi
Howard Hughes Medical Institute and Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9050, USA.
Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):1045-50. doi: 10.1073/pnas.2637002100. Epub 2004 Jan 13.
Leptin is an adipose-derived hormone that regulates a wide variety of physiological processes, including feeding behavior, metabolic rate, sympathetic nerve activity, reproduction, and immune response. Circulating leptin levels are tightly regulated according to energy homeostasis in vivo. Although mechanisms for the regulation of leptin production in adipocytes are not well understood, G protein-coupled receptors may play an important role in this adipocyte function. Here we report that C2-C6 short-chain fatty acids, ligands of an orphan G protein-coupled receptor GPR41, stimulate leptin expression in both a mouse adipocyte cell line and mouse adipose tissue in primary culture. Acute oral administration of propionate increases circulating leptin levels in mice. The concentrations of short-chain fatty acids required to stimulate leptin production are within physiological ranges, suggesting the relevance of this pathway in vivo.
瘦素是一种由脂肪组织分泌的激素，可调节多种生理过程，包括摄食行为、代谢率、交感神经活动、生殖和免疫反应。体内循环中的瘦素水平根据能量稳态受到严格调控。尽管脂肪细胞中瘦素产生的调控机制尚不完全清楚，但G蛋白偶联受体可能在这种脂肪细胞功能中发挥重要作用。在此我们报告，孤儿G蛋白偶联受体GPR41的配体C2 - C6短链脂肪酸可刺激小鼠脂肪细胞系和原代培养的小鼠脂肪组织中的瘦素表达。急性口服丙酸盐可提高小鼠循环中的瘦素水平。刺激瘦素产生所需的短链脂肪酸浓度在生理范围内，表明该途径在体内具有相关性。
