van Asten Liselotte, Verhaest Inge, Lamzira Saida, Hernandez-Aguado Ildefonso, Zangerle Robert, Boufassa Faroudy, Rezza Giovanni, Broers Barbara, Robertson J Roy, Brettle Raymond P, McMenamin Jim, Prins Maria, Cochrane Alexandra, Simmonds Peter, Coutinho Roel A, Bruisten Sylvia
Municipal Health Service, Cluster of Infectious Diseases, Amsterdam, The Netherlands.
J Infect Dis. 2004 Jan 15;189(2):292-302. doi: 10.1086/380821. Epub 2004 Jan 8.
To describe the spread of hepatitis C virus (HCV) among HCV/human immunodeficiency virus (HIV)-coinfected injection drug users (IDUs), the molecular epidemiology of HCV was studied among 108 IDUs from 7 European countries. Phylogenetic analysis based on the NS5B region showed great sequence variation of HCV within each country and no clear phylogenetic clustering by geographic region. The most prevalent subtypes were 1a and 3a, but the percentage of genotype 4 was also relatively high, ranging from 7% in northern Europe to 24% in southern Europe. Genotype 4 consisted mainly of subtype 4d and has entered the majority of the IDU populations studied. The significantly lower evolutionary distances within subtype 4d suggest that this subtype may have entered the European IDU population relatively recently. In conclusion, HCV exchange between European IDU populations has occurred on a large scale, and, overall, country-specific clustering for HCV was less than that shown for HIV.
为描述丙型肝炎病毒（HCV）在HCV/人类免疫缺陷病毒（HIV）合并感染的注射吸毒者（IDU）中的传播情况，对来自7个欧洲国家的108名IDU进行了HCV分子流行病学研究。基于NS5B区域的系统发育分析显示，每个国家内HCV序列变异很大，且未按地理区域形成明显的系统发育聚类。最常见的亚型是1a和3a，但4型基因型的比例也相对较高，从北欧的7%到南欧的24%不等。4型基因型主要由4d亚型组成，且已进入大多数所研究的IDU人群。4d亚型内显著更低的进化距离表明，该亚型可能是相对近期才进入欧洲IDU人群的。总之，欧洲IDU人群之间已大规模发生HCV交换，总体而言，HCV的国家特异性聚类少于HIV的情况。
