David Kim P, Alifrangis Michael, Salanti Ali, Vestergaard Lasse S, Rønn Anita, Bygbjerg I B
Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
Scand J Infect Dis. 2003;35(11-12):897-8.
The Atovaquone/proguanil combination has quickly been established as an effective chemoprophylaxis for travellers to areas with chloroquineresistant Plasmodium falciparum malaria. We describe the molecular cause of the first reported case of primary Atovaquone/proguanil resistance observed in our department in a Plasmodium falciparum infected traveller returning from West Africa, and link our findings to other reports of resistance.
阿托伐醌/氯胍组合已迅速成为前往有耐氯喹恶性疟原虫疟疾地区旅行者的有效化学预防药物。我们描述了在我们科室观察到的首例原发性阿托伐醌/氯胍耐药病例的分子原因，该病例发生在一名从西非返回的感染恶性疟原虫的旅行者身上，并将我们的发现与其他耐药报告联系起来。
