Climstein M, O'Shea P, Adams K J, DeBeliso M
Faculty of Health Sciences, Australian Catholic University, Department of Rehabilitation, Harbord Diggers' Memorial, Sydney, Australia.
J Sci Med Sport. 2003 Dec;6(4):387-97. doi: 10.1016/s1440-2440(03)80265-7.
Previous investigations reported alterations in myocardial fibres and systolic function associated with anabolic-androgenic steroid consumption by athletes. Advances in bio-medical technology have allowed further investigation in assessing the possible effects of anabolic-androgenic steroids on gross left ventricular kinetics. Twenty-three male strength and power athletes with a past and current history of anabolic-androgenic steroid consumption (x 46 days, range 28 days to 70 days), were compared to 23 controls. Testing consisted of resting and immediate post-exercise transthoracic left ventricular wall cardiokymograms. Statistical results identified no difference over time between groups or condition. Cardiokymographic waveform analysis found 32.61% of all (n =184) waveforms to be abnormal (Type II, n = 56 or Type III, n = 4). There were 14 treatment subjects (60.87%) who demonstrated an abnormal waveform as compared to 9 controls (39.13%). A significant difference (p < or = 0.01) in the overall proportions of waveform types was identified where the treatment group exhibited 41.30% abnormal waveforms, compared to 23.91% by controls. Additionally, two athletes (1 treatment, 1 control) demonstrated abnormal left ventricular wall motions (Type III) analogous to impaired left ventricular performance. The results indicated: (a) highly strength trained athletes with no history of anabolic-androgenic steroid usage exhibited an unexpected high incidence of Type II waveforms (28.26% pre/23.91% post); (b) a comparable group of strength trained athletes using anabolic-androgenic steroids exhibited a significantly higher percentage of abnormal waveforms as compared to controls (34.78% pre/37.21% post). Based on these results, high intensity strength training with and without anabolic-androgenic steroid supplementation induced alterations in the left ventricular wall motion.
先前的调查报道了运动员使用合成代谢雄激素类固醇与心肌纤维及收缩功能改变有关。生物医学技术的进步使得进一步研究评估合成代谢雄激素类固醇对左心室整体动力学的可能影响成为可能。将23名有合成代谢雄激素类固醇使用史（过去和现在，平均46天，范围28天至70天）的男性力量和爆发力运动员与23名对照组进行比较。测试包括静息和运动后即刻经胸左心室壁心动图。统计结果表明，两组之间或不同状态随时间无差异。心动图波形分析发现，所有波形（n = 184）中有32.61%异常（II型，n = 56或III型，n = 4）。有14名受试运动员（60.87%）出现异常波形，而对照组为9名（39.13%）。波形类型的总体比例存在显著差异（p≤0.01），治疗组异常波形比例为41.30%，而对照组为23.91%。此外，两名运动员（一名受试运动员，一名对照）表现出与左心室功能受损类似的左心室壁异常运动（III型）。结果表明：（a）无合成代谢雄激素类固醇使用史的高强度训练运动员出现II型波形的发生率出乎意料地高（训练前28.26%/训练后23.91%）；（b）一组使用合成代谢雄激素类固醇的力量训练运动员与对照组相比，异常波形百分比显著更高（训练前34.78%/训练后37.21%）。基于这些结果，无论是否补充合成代谢雄激素类固醇，高强度力量训练都会引起左心室壁运动的改变。
