Nottin Stéphane, Nguyen Long-Dang, Terbah Mohamed, Obert Philippe
Laboratory of Cardiovascular Adaptations to Exercise, Faculty of Sciences, Avignon, France.
Am J Cardiol. 2006 Mar 15;97(6):912-5. doi: 10.1016/j.amjcard.2005.10.026. Epub 2006 Feb 2.
The effects of anabolic androgenic steroids (AASs) on left ventricular (LV) diastolic function in strength-trained athletes are controversial. The main objective of this study was to evaluate the effects of regular AAS administration in bodybuilders using pulsed tissue Doppler imaging (TDI) to evaluate LV relaxation properties. Fifteen male bodybuilders with a history of intensive, long-term strength training and 16 age-matched sedentary controls were recruited. Six of the bodybuilders reported regular use of AASs, and 9 were drug free. To assess LV diastolic function, each subject underwent standard Doppler echocardiography and pulsed TDI. Drug-using bodybuilders exhibited altered LV diastolic filling characterized by a smaller contribution of passive filling to LV filling compared with their drug-free counterparts. TDI measurements indicated that drug-using bodybuilders had smaller peak E(m) than drug-free bodybuilders and sedentary controls, except at the level of the anterior wall, at which peak E(m) was significantly smaller than in drug-free bodybuilders only. The E/E(m) ratio, an index of LV filling pressures, was not affected by strength training or by AAS use. Drug-using bodybuilders exhibited larger LV end-diastolic diameters, volumes, and masses than their drug-free counterparts. However, no difference was found in LV wall thickness between the groups. In conclusion, drug-using bodybuilders showed a decrease in the contribution in LV passive filling to LV filling associated with a decrease in LV relaxation properties. Because no wall thickening was obtained in drug-using bodybuilders, the decrease in LV relaxation properties might have been be due to an alteration in the active properties of the myocardium, but that has yet to be confirmed.
合成代谢雄激素类固醇（AASs）对力量训练运动员左心室（LV）舒张功能的影响存在争议。本研究的主要目的是通过脉冲组织多普勒成像（TDI）评估左心室舒张特性，以评价定期使用AASs对健美运动员的影响。招募了15名有长期高强度力量训练史的男性健美运动员和16名年龄匹配的久坐不动的对照者。其中6名健美运动员报告经常使用AASs，9名未使用药物。为了评估左心室舒张功能，每位受试者均接受了标准多普勒超声心动图检查和脉冲TDI检查。与未使用药物的健美运动员相比，使用药物的健美运动员左心室舒张期充盈发生改变，其特点是被动充盈对左心室充盈的贡献较小。TDI测量表明，使用药物的健美运动员的E（m）峰值小于未使用药物的健美运动员和久坐不动的对照者，但在前壁水平除外，在前壁水平，E（m）峰值仅显著小于未使用药物的健美运动员。E/E（m）比值是左心室充盈压力的一个指标，不受力量训练或AAS使用的影响。使用药物的健美运动员的左心室舒张末期直径、容积和质量均大于未使用药物的健美运动员。然而，两组之间的左心室壁厚度没有差异。总之，使用药物的健美运动员左心室被动充盈对左心室充盈的贡献减少，同时左心室舒张特性降低。由于使用药物的健美运动员未出现心肌增厚，左心室舒张特性的降低可能是由于心肌活性特性的改变，但这一点尚未得到证实。
