Cicuttini F M, Wluka A E, Stuckey S L
Department of Epidemiology and Preventive Medicine, Monash University Medical School, Alfred Hospital, Prahran, Victoria 3181, Australia.
Ann Rheum Dis. 2001 Oct;60(10):977-80. doi: 10.1136/ard.60.10.977.
Despite the increasing interest in using knee cartilage volume as an outcome measure in studies of osteoarthritis (OA), it is unclear what components of knee cartilage will be most useful as markers of structure in the tibiofemoral (TF) joint.
To compare the changes that occur in femoral and tibial cartilage volume in normal and osteoarthritic knees and how they relate to radiological grade.
82 subjects (44 female, 38 male, age range 35-69 years) with a spectrum of radiological knee OA were examined. Each subject had femoral and tibial cartilage volume in the medial and lateral TF joint determined from T(1) weighted fat saturated magnetic resonance images of the knee. Radiological grade of OA was determined from standing knee radiographs.
There was strong correlation between femoral and tibial cartilage volume measured in both the medial (R=0.75, p<0.001) and lateral TF joint (R=0.77, p<0.001). Similar correlations persisted when those with normal and those with OA joints were examined separately at both the medial and lateral TF joint. For each increase in radiological grade of joint space narrowing (0-3), there was a mean (SD) reduction in tibial cartilage volume of 1.00 (0.32) ml in the medial compartment and 0.53 (0.25) ml in the lateral compartment, after adjusting for differences in bone size. Similar changes were seen in the femoral cartilage.
The amounts of tibial and femoral cartilage are strongly related. It may be that for TF joint disease, measuring tibial cartilage alone may be adequate, given that measurements of the total femoral cartilage are less reproducible and the difficulties inherent in identifying the most appropriate component of femoral cartilage to measure.
尽管在骨关节炎（OA）研究中，将膝关节软骨体积作为一项结果指标的兴趣日益浓厚，但尚不清楚膝关节软骨的哪些组成部分作为胫股（TF）关节结构标志物最为有用。
比较正常膝关节和骨关节炎膝关节中股骨和胫骨软骨体积的变化，以及它们与放射学分级的关系。
对82例（44例女性，38例男性，年龄范围35 - 69岁）具有一系列膝关节OA放射学表现的受试者进行检查。通过膝关节的T1加权脂肪饱和磁共振成像确定每个受试者TF关节内侧和外侧的股骨和胫骨软骨体积。OA的放射学分级通过站立位膝关节X线片确定。
在内侧（R = 0.75，p < 0.001）和外侧TF关节（R = 0.77，p < 0.001）测量的股骨和胫骨软骨体积之间存在强相关性。在内侧和外侧TF关节分别对正常关节和OA关节的受试者进行检查时，类似的相关性依然存在。在调整骨大小差异后，关节间隙狭窄放射学分级每增加一级（0 - 3级），内侧胫骨软骨体积平均（标准差）减少1.00（0.32）ml，外侧减少0.53（0.25）ml。股骨软骨也有类似变化。
胫骨和股骨软骨量密切相关。对于TF关节疾病，鉴于测量整个股骨软骨的重复性较差以及确定要测量的股骨软骨最合适组成部分存在固有困难，单独测量胫骨软骨可能就足够了。
