Shi Li-Shian, Kuo Ping-Chung, Tsai Yao-Lung, Damu Amooru Gangaiah, Wu Tian-Shung
Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan, ROC.
Bioorg Med Chem. 2004 Jan 15;12(2):439-46. doi: 10.1016/j.bmc.2003.10.031.
Two new aristolactams, aristolactam E (1) and aristolactam-AIIIa-6-O-beta-D-glucoside (2), three novel benzoyl benzyltetrahydroisoquinoline ether N-oxide alkaloids, aristoquinoline A (3), aristoquinoline B (4), and aristoquinoline C (5), and a new biphenyl ether, aristogin F (6), together with 62 known compounds have been isolated from the root and stem of Aristolochia elegans Mast. The structures of the new natural products were established on the basis of spectral evidence. Some of the isolated compounds were examined for their antioxidative and antityrosinase activities. Occurrence of the isoquinolones, biphenyl ethers, and benzoyl benzyltetrahydroisoquinoline ether alkaloids in the same plant indicated the definite possibility of these metabolites as biotransformation intermediates of bisbenzyltetrahydroisoquinoline alkaloids. This can be useful to solve the catabolic process of bisbenzyltetrahydroisoquinoline alkaloids.
从马兜铃的根和茎中分离出了两种新的马兜铃内酰胺，即马兜铃内酰胺E（1）和马兜铃内酰胺 - AIIIa - 6 - O - β - D - 葡萄糖苷（2），三种新型的苯甲酰基苄基四氢异喹啉醚氮氧化物生物碱，即马兜喹啉A（3）、马兜喹啉B（4）和马兜喹啉C（5），以及一种新的联苯醚，即马兜精F（6），同时还分离出了62种已知化合物。新天然产物的结构是根据光谱证据确定的。对部分分离出的化合物进行了抗氧化和抗酪氨酸酶活性检测。同一植物中异喹诺酮类、联苯醚类和苯甲酰基苄基四氢异喹啉醚生物碱的存在表明，这些代谢产物作为双苄基四氢异喹啉生物碱生物转化中间体具有一定可能性。这对于解决双苄基四氢异喹啉生物碱的分解代谢过程可能会有所帮助。
