Ysrael Mafel C
Pharmacy and Research Center for the Natural Sciences, University of Santo Tomas, España, Manila 1008, Philippines.
Clin Hemorheol Microcirc. 2003;29(3-4):247-51.
Ipomoea muricata (L.) Jacq, locally known as 'Tonkin', has been used for generations by the Dominicans in the Philippines for medicinal purposes. The seeds, stems and leaves are said to be effective in treating several types of skin ailments such as chronic and gangrenous wounds, cuts and blisters due to burns. Scientific investigations to rationalize the reported medicinal uses of the plant were carried out at University of Santo Tomas. Botanists at the University did the identification and studied the cultivation and propagation of the plant. Pharmacists and chemists worked closely together on the 'Tonkin' seeds. The seeds were found to have both analgesic and antiseptic properties. Chemists identified indolizidine alkaloids in the seeds, to which the analgesic properties have been attributed. Antimicrobial and antifungal compounds were also identified. Different formulations of the crude drug have been made, namely, an ointment for the treatment of skin ailments, glycerol preparation for the treatment of pharyngitis and an otic preparation for the treatment of otitis externa. Limited clinical trials of these formulations were carried out in collaboration with the medical doctors. The clinical trial studies were supported by in vitro studies carried out by microbiologists. Basic research on this plant material is still continuing. Efforts are now underway for the commercial production of the Tonkin ointment.
紫茉莉（Ipomoea muricata (L.) Jacq），当地称作“东京紫茉莉”，菲律宾的多米尼加人已世代将其用于药用。据说其种子、茎和叶对治疗多种皮肤疾病有效，如慢性和坏疽性伤口、烧伤所致的割伤和水泡。圣托马斯大学对该植物的上述药用功效进行了科学研究。该校植物学家对其进行了鉴定，并研究了其种植与繁殖。药剂师和化学家密切合作研究“东京紫茉莉”种子。发现这些种子具有止痛和防腐特性。化学家在种子中鉴定出了吲哚里西啶生物碱，止痛特性即归因于此。还鉴定出了抗菌和抗真菌化合物。已制备了该生药的不同制剂，即用于治疗皮肤疾病的软膏、用于治疗咽炎的甘油制剂和用于治疗外耳道炎的耳用制剂。这些制剂与医生合作进行了有限的临床试验。临床试验研究得到了微生物学家进行的体外研究的支持。对这种植物材料的基础研究仍在继续。目前正在努力实现东京紫茉莉软膏的商业化生产。
