Vermeulen C, Mathelier-Fusade P, Rouquette A-M, Bayrou O, Pecquet C, Leynadier F
Centre d'Allergologie, Hôpital Tenon, Paris.
Ann Dermatol Venereol. 2003 Dec;130(12 Pt 1):1115-8.
The autoimmune nature of certain forms of chronic urticaria remains debatable. Aim of the study. To find a correlation in terms of autoimmune pattern between chronic urticaria and thyroiditis using the autologous serum test and the search for anti-thyroid antibodies.
Study in a single center of 59 patients having consulted for urticaria that had progressed for more than six weeks and without precise etiology. An autologous serum test was conducted and anti-thyroid autoantibodies were searched for in the serum stored after the test.
Out of 59 patients, 51 had an interpretable autologous serum test and 57 underwent research for anti-thyroid antibodies. Twelve patients out 57 (21 p.cent) exhibited one or more types of positive (n=10) or borderline (n=2) anti-thyroid antibodies, and eight out of 12 (66.6 p.cent) had a known thyroid disease before the onset of urticaria. The systematic blood test permitted the discovery of 4 cases of unknown anti-thyroid antibodies. The symptoms regressed in two of these patients without any specific treatment, one patient was treated with L thyroxin for hyperthyroidism without any improvement in the symptoms and one other patient had normal thyroid function. Among these 12 patients, 11 underwent autologous serum tests, but only 3 of them exhibited clearly positive results and one was doubtful.
Within the limits of this study, we found a 21 p.cent rate of patients with chronic urticaria exhibiting one or more anti-thyroid antibodies. The positivity of the autologous serum test does not appear to be related with autoimmune thyroid disorders.
某些形式的慢性荨麻疹的自身免疫性质仍存在争议。研究目的。使用自体血清试验和检测抗甲状腺抗体，寻找慢性荨麻疹与甲状腺炎在自身免疫模式方面的相关性。
在单一中心对59例因荨麻疹就诊且病程超过六周且病因不明的患者进行研究。进行了自体血清试验，并在试验后储存的血清中检测抗甲状腺自身抗体。
59例患者中，51例自体血清试验结果可解读，57例接受了抗甲状腺抗体检测。57例患者中有12例（21%）出现一种或多种阳性（n = 10）或临界（n = 2）抗甲状腺抗体，12例中有8例（66.6%）在荨麻疹发作前就患有已知的甲状腺疾病。系统血液检测发现了4例未知的抗甲状腺抗体病例。其中2例患者未经任何特殊治疗症状消退，1例因甲状腺功能亢进接受左甲状腺素治疗但症状无改善，另1例甲状腺功能正常。在这12例患者中，11例进行了自体血清试验，但只有3例结果呈明显阳性，1例结果可疑。
在本研究范围内，我们发现21%的慢性荨麻疹患者存在一种或多种抗甲状腺抗体。自体血清试验的阳性结果似乎与自身免疫性甲状腺疾病无关。
